Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model

The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, suc...

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Bibliographic Details
Published in:Phytotherapy research 2002-05, Vol.16 (3), p.217-222
Main Authors: Kasahara, Yoshimasa, Yasukawa, Ken, Kitanaka, Susumu, Khan, M. Taufiq, Evans, Fred J.
Format: Article
Language:English
Subjects:
Acetic Acid - pharmacology
acute and chronic inflammation
Acute Disease
Alprostadil - pharmacology
Animals
antiinflammation
Biological and medical sciences
Bradykinin - pharmacology
Capillary Permeability - drug effects
Carrageenan - pharmacology
Chronic Disease
compositae
Flowers - chemistry
General pharmacology
Granulation Tissue - drug effects
Hindlimb - drug effects
Histamine - pharmacology
Inflammation - chemically induced
Inflammation - drug therapy
Male
Medical sciences
Methanol - chemistry
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Serotonin - pharmacology
Tagetes
Tagetes patula
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Summary:The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E1, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1099