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Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model
The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, suc...
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| Published in: | Phytotherapy research 2002-05, Vol.16 (3), p.217-222 |
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| container_end_page | 222 |
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| container_title | Phytotherapy research |
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| creator | Kasahara, Yoshimasa Yasukawa, Ken Kitanaka, Susumu Khan, M. Taufiq Evans, Fred J. |
| description | The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E1, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1099 |
| format | article |
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Taufiq ; Evans, Fred J.</creator><creatorcontrib>Kasahara, Yoshimasa ; Yasukawa, Ken ; Kitanaka, Susumu ; Khan, M. Taufiq ; Evans, Fred J.</creatorcontrib><description>The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E1, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. 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Drug treatments ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Serotonin - pharmacology ; Tagetes ; Tagetes patula</subject><ispartof>Phytotherapy research, 2002-05, Vol.16 (3), p.217-222</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4199-cd806b2ac2fff4e637457f69eb90139117e9113d24801bae4e0e21e5c90c1a3d3</citedby><cites>FETCH-LOGICAL-c4199-cd806b2ac2fff4e637457f69eb90139117e9113d24801bae4e0e21e5c90c1a3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13665057$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12164264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasahara, Yoshimasa</creatorcontrib><creatorcontrib>Yasukawa, Ken</creatorcontrib><creatorcontrib>Kitanaka, Susumu</creatorcontrib><creatorcontrib>Khan, M. Taufiq</creatorcontrib><creatorcontrib>Evans, Fred J.</creatorcontrib><title>Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E1, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>Acetic Acid - pharmacology</subject><subject>acute and chronic inflammation</subject><subject>Acute Disease</subject><subject>Alprostadil - pharmacology</subject><subject>Animals</subject><subject>antiinflammation</subject><subject>Biological and medical sciences</subject><subject>Bradykinin - pharmacology</subject><subject>Capillary Permeability - drug effects</subject><subject>Carrageenan - pharmacology</subject><subject>Chronic Disease</subject><subject>compositae</subject><subject>Flowers - chemistry</subject><subject>General pharmacology</subject><subject>Granulation Tissue - drug effects</subject><subject>Hindlimb - drug effects</subject><subject>Histamine - pharmacology</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methanol - chemistry</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin - pharmacology</subject><subject>Tagetes</subject><subject>Tagetes patula</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EosuCxC9AvoC4pNix8-EjWrWl6goQWlRu1qwzpilOnNqO2v57vNqInrh4LM-jZ6x3CHnL2SlnrPw0pZAvSj0jq0MpeNWI52TFVMULydtfJ-RVjLeMMVUy-ZKc8JLXsqzlityeWYsmUW_pgOkGRu8oPqQA-c0GP1Dr_D0GOmECFw_YDn5jwkgnSLMDuj2lfqRg5oQUxo6am-DH3tB-tA6GAVKf24Pv0L0mL2x24JulrsnP87Pd5kux_XZxufm8LYzk-e-ma1m9L8GU1lqJtWhk1dha4V4xLhTnDeZDdKVsGd8DSmRYcqyMYoaD6MSafDh6p-DvZoxJD3006ByM6OeoG67abFEZ_HgETfAxBrR6Cv0A4VFzpg-56pyrPgSa0XeLc94P2D2BS5AZeL8AEA04G2A0fXziRF1XLG9lTYojd987fPzvQP1992MZvPB9TPjwj4fwR9eNaCp9_fVCn4t2e3W9yQ7xFyaKndc</recordid><startdate>200205</startdate><enddate>200205</enddate><creator>Kasahara, Yoshimasa</creator><creator>Yasukawa, Ken</creator><creator>Kitanaka, Susumu</creator><creator>Khan, M. Taufiq</creator><creator>Evans, Fred J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200205</creationdate><title>Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model</title><author>Kasahara, Yoshimasa ; Yasukawa, Ken ; Kitanaka, Susumu ; Khan, M. Taufiq ; Evans, Fred J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4199-cd806b2ac2fff4e637457f69eb90139117e9113d24801bae4e0e21e5c90c1a3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetic Acid - pharmacology</topic><topic>acute and chronic inflammation</topic><topic>Acute Disease</topic><topic>Alprostadil - pharmacology</topic><topic>Animals</topic><topic>antiinflammation</topic><topic>Biological and medical sciences</topic><topic>Bradykinin - pharmacology</topic><topic>Capillary Permeability - drug effects</topic><topic>Carrageenan - pharmacology</topic><topic>Chronic Disease</topic><topic>compositae</topic><topic>Flowers - chemistry</topic><topic>General pharmacology</topic><topic>Granulation Tissue - drug effects</topic><topic>Hindlimb - drug effects</topic><topic>Histamine - pharmacology</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methanol - chemistry</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin - pharmacology</topic><topic>Tagetes</topic><topic>Tagetes patula</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasahara, Yoshimasa</creatorcontrib><creatorcontrib>Yasukawa, Ken</creatorcontrib><creatorcontrib>Kitanaka, Susumu</creatorcontrib><creatorcontrib>Khan, M. Taufiq</creatorcontrib><creatorcontrib>Evans, Fred J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasahara, Yoshimasa</au><au>Yasukawa, Ken</au><au>Kitanaka, Susumu</au><au>Khan, M. Taufiq</au><au>Evans, Fred J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2002-05</date><risdate>2002</risdate><volume>16</volume><issue>3</issue><spage>217</spage><epage>222</epage><pages>217-222</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The methanol extract of the florets of Tagetes patula (MEFTP) inhibited acute and chronic inflammation in mice and rats. MEFTP significantly suppressed hind‐paw oedema induced by γ‐carrageenin in mice. Furthermore, MEFTP not only inhibited the hind‐paw oedema induced by various acute phlogogens, such as histamine, serotonin, bradykinin and prostaglandin E1, but also suppressed the increase of vascular permeability by acetic acid, indicating that it primarily acts at the exudative stage of inflammation. In the chronic inflammation, MEFTP did not inhibit the proliferation of granulation tissue when tested by the cotton pellet method, however, it was effective on the development of adjuvant arthritis in rats. Oral MEFTP inhibited acute and chronic inflammation in mice and rats. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>12164264</pmid><doi>10.1002/ptr.1099</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic Acid - pharmacology acute and chronic inflammation Acute Disease Alprostadil - pharmacology Animals antiinflammation Biological and medical sciences Bradykinin - pharmacology Capillary Permeability - drug effects Carrageenan - pharmacology Chronic Disease compositae Flowers - chemistry General pharmacology Granulation Tissue - drug effects Hindlimb - drug effects Histamine - pharmacology Inflammation - chemically induced Inflammation - drug therapy Male Medical sciences Methanol - chemistry Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Serotonin - pharmacology Tagetes Tagetes patula |
| title | Effect of methanol extract from flower petals of Tagetes patula L. on acute and chronic inflammation model |
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