Apoptosis and cell proliferation in the development of gastric carcinomas: Associations with c-myc and p53 protein expression

Background and Aim: Patients with gastric carcinomas have a poor prognosis and low survival rates. The aim of the present paper was to characterize cellular and molecular properties to provide insight into aspects of tumor progression in early compared with advanced gastric cancers. Methods: One hun...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2002-09, Vol.17 (9), p.966-972
Main Authors: Ishii, Hideaki H, Gobé, Glenda C, Pan, Wenshen, Yoneyama, Juichi, Ebihara, Yoshiro
Format: Article
Language:English
Subjects:
adenocarcinoma
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Antigens, Neoplasm - metabolism
Apoptosis
Biological and medical sciences
Cell Division
Digestive system
Humans
Immunoenzyme Techniques
In Situ Nick-End Labeling
Investigative techniques, diagnostic techniques (general aspects)
Ki-67
Ki-67 Antigen - metabolism
Medical sciences
Neoplasm Staging
oncogenes
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proto-Oncogene Proteins c-myc - biosynthesis
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
tumor suppressor genes
Tumor Suppressor Protein p53 - biosynthesis
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Summary:Background and Aim: Patients with gastric carcinomas have a poor prognosis and low survival rates. The aim of the present paper was to characterize cellular and molecular properties to provide insight into aspects of tumor progression in early compared with advanced gastric cancers. Methods: One hundred and nine graded gastric carcinomas (early or advanced stage, undifferentiated or differentiated type) with paired non‐cancer tissue were studied to define the correlation between apoptosis (morphology, terminal deoxyribonucleotidyl transferase‐mediated dUTP–digoxigenin nick end‐labeling), cell proliferation (Ki‐67 expression, morphology) and expression and localization of two proteins frequently having altered expression in cancers, namely p53 and c‐myc. Results: Overall, apoptosis was lower in early stage, differentiated and undifferentiated gastric carcinomas compared with advanced‐stage cancers. Cell proliferation was comparatively high in all stages. There was a high level of p53 positivity in all stages. Only the early‐ and advanced‐stage undifferentiated cancers that were p53 positive had a significantly higher level of apoptosis (P 
ISSN:0815-9319
1440-1746
DOI:10.1046/j.1440-1746.2002.02805.x