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Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats
In traditional Oriental medicine, Uncaria rhynchophylla has been used to lower blood pressure and to relieve various neurological symptoms. However, scientific evidence related to its effectiveness or precise modes of action has not been available. Thus, in the current study, we evaluated neuroprote...
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| Published in: | Life sciences (1973) 2002-04, Vol.70 (21), p.2467-2480 |
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| Main Authors: | , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c479t-5bab8e0cb95d64bf250dbc42de9dbf1ef1d459046097e729cc38005d40b566003 |
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| cites | cdi_FETCH-LOGICAL-c479t-5bab8e0cb95d64bf250dbc42de9dbf1ef1d459046097e729cc38005d40b566003 |
| container_end_page | 2480 |
| container_issue | 21 |
| container_start_page | 2467 |
| container_title | Life sciences (1973) |
| container_volume | 70 |
| creator | Suk, Kyoungho Kim, Sun Yeou Leem, Kanghyun Kim, Young Ock Park, Sun Young Hur, Jinyoung Baek, Jihwoon Lee, Kang Jin Zheng, Hu Zhan Kim, Hocheol |
| description | In traditional Oriental medicine,
Uncaria rhynchophylla has been used to lower blood pressure and to relieve various neurological symptoms. However, scientific evidence related to its effectiveness or precise modes of action has not been available. Thus, in the current study, we evaluated neuroprotective effects of
U. rhynchophylla after transient global ischemia using 4-vessel occlusion model in rats. Methanol extract of
U. rhynchophylla administered intraperitoneally (100–1000 mg/kg at 0 and 90 min after reperfusion) significantly protected hippocampal CA1 neurons against 10 min transient forebrain ischemia. Measurement of neuronal cell density in CA1 region at 7 days after ischemia by Nissl staining revealed more than 70% protection in
U. rhynchophylla-treated rats compared to saline-treated animals. In
U. rhynchophylla-treated animals, induction of cyclooxygenase-2 in hippocampus at 24 hr after ischemia was significantly inhibited at both mRNA and protein levels. Furthermore,
U. rhynchophylla extract inhibited TNF-α and nitric oxide production in BV-2 mouse microglial cells
in vitro. These anti-inflammatory actions of
U. rhynchophylla extract may contribute to its neuroprotective effects. |
| doi_str_mv | 10.1016/S0024-3205(02)01534-5 |
| format | article |
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Uncaria rhynchophylla has been used to lower blood pressure and to relieve various neurological symptoms. However, scientific evidence related to its effectiveness or precise modes of action has not been available. Thus, in the current study, we evaluated neuroprotective effects of
U. rhynchophylla after transient global ischemia using 4-vessel occlusion model in rats. Methanol extract of
U. rhynchophylla administered intraperitoneally (100–1000 mg/kg at 0 and 90 min after reperfusion) significantly protected hippocampal CA1 neurons against 10 min transient forebrain ischemia. Measurement of neuronal cell density in CA1 region at 7 days after ischemia by Nissl staining revealed more than 70% protection in
U. rhynchophylla-treated rats compared to saline-treated animals. In
U. rhynchophylla-treated animals, induction of cyclooxygenase-2 in hippocampus at 24 hr after ischemia was significantly inhibited at both mRNA and protein levels. Furthermore,
U. rhynchophylla extract inhibited TNF-α and nitric oxide production in BV-2 mouse microglial cells
in vitro. These anti-inflammatory actions of
U. rhynchophylla extract may contribute to its neuroprotective effects.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(02)01534-5</identifier><identifier>PMID: 12173411</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Blotting, Western ; Cell Death - drug effects ; Cell Line ; Cyclooxygenase ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors - pharmacology ; Dinoprostone - biosynthesis ; Dinoprostone - genetics ; Hippocampus - pathology ; Immunohistochemistry ; Indicators and Reagents ; Ischemia ; Ischemic Attack, Transient - drug therapy ; Ischemic Attack, Transient - pathology ; Isoenzymes - metabolism ; Mice ; Neurons - drug effects ; Neuroprotection ; Neuroprotective Agents - pharmacology ; Nitric Oxide - biosynthesis ; Nitric Oxide - metabolism ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots - chemistry ; Plant Stems - chemistry ; Plants, Medicinal - chemistry ; Prostaglandin-Endoperoxide Synthases - metabolism ; Rats ; Rats, Wistar ; Reverse Transcriptase Polymerase Chain Reaction ; Rubiaceae - chemistry ; TNF-α ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - metabolism ; Uncaria rhynchophylla</subject><ispartof>Life sciences (1973), 2002-04, Vol.70 (21), p.2467-2480</ispartof><rights>2002 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-5bab8e0cb95d64bf250dbc42de9dbf1ef1d459046097e729cc38005d40b566003</citedby><cites>FETCH-LOGICAL-c479t-5bab8e0cb95d64bf250dbc42de9dbf1ef1d459046097e729cc38005d40b566003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12173411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suk, Kyoungho</creatorcontrib><creatorcontrib>Kim, Sun Yeou</creatorcontrib><creatorcontrib>Leem, Kanghyun</creatorcontrib><creatorcontrib>Kim, Young Ock</creatorcontrib><creatorcontrib>Park, Sun Young</creatorcontrib><creatorcontrib>Hur, Jinyoung</creatorcontrib><creatorcontrib>Baek, Jihwoon</creatorcontrib><creatorcontrib>Lee, Kang Jin</creatorcontrib><creatorcontrib>Zheng, Hu Zhan</creatorcontrib><creatorcontrib>Kim, Hocheol</creatorcontrib><title>Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>In traditional Oriental medicine,
Uncaria rhynchophylla has been used to lower blood pressure and to relieve various neurological symptoms. However, scientific evidence related to its effectiveness or precise modes of action has not been available. Thus, in the current study, we evaluated neuroprotective effects of
U. rhynchophylla after transient global ischemia using 4-vessel occlusion model in rats. Methanol extract of
U. rhynchophylla administered intraperitoneally (100–1000 mg/kg at 0 and 90 min after reperfusion) significantly protected hippocampal CA1 neurons against 10 min transient forebrain ischemia. Measurement of neuronal cell density in CA1 region at 7 days after ischemia by Nissl staining revealed more than 70% protection in
U. rhynchophylla-treated rats compared to saline-treated animals. In
U. rhynchophylla-treated animals, induction of cyclooxygenase-2 in hippocampus at 24 hr after ischemia was significantly inhibited at both mRNA and protein levels. Furthermore,
U. rhynchophylla extract inhibited TNF-α and nitric oxide production in BV-2 mouse microglial cells
in vitro. These anti-inflammatory actions of
U. rhynchophylla extract may contribute to its neuroprotective effects.</description><subject>Animals</subject><subject>Blotting, Western</subject><subject>Cell Death - drug effects</subject><subject>Cell Line</subject><subject>Cyclooxygenase</subject><subject>Cyclooxygenase 2</subject><subject>Cyclooxygenase 2 Inhibitors</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Dinoprostone - biosynthesis</subject><subject>Dinoprostone - genetics</subject><subject>Hippocampus - pathology</subject><subject>Immunohistochemistry</subject><subject>Indicators and Reagents</subject><subject>Ischemia</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Isoenzymes - metabolism</subject><subject>Mice</subject><subject>Neurons - drug effects</subject><subject>Neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide - metabolism</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots - chemistry</subject><subject>Plant Stems - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rubiaceae - chemistry</subject><subject>TNF-α</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Uncaria rhynchophylla</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkEtP3DAURq2qqDPQ_oQir6qyCFwndjJZIYR4VEKwaFlbftxMXCXxYDuo8-8xzAiWXd27OPfxHUK-MzhlwOqz3wAlL6oSxE8oT4CJihfiE1myVdMWUFfsM1m-IwtyGONfABCiqb6QBStZU3HGlgTvcQ5-E3xCk5yfqN7SEVOvJj9Q_JeCMon6jj5ORgWnaOi3k-n9pt8Og6JqrdwUE10PXquBGgyoQ25cND2OGXcTDSrFr-SgU0PEb_t6RB6vr_5c3hZ3Dze_Li_uCsObNhVCK71CMLoVtua6KwVYbXhpsbW6Y9gxy0ULvIa2waZsjalWOZPloEVdA1RH5Mdubw70NGNMcsyvYH51Qj9H2bB2xWvBMih2oAk-xoCd3AQ3qrCVDOSrX_nmV77Kk1DKN79S5Lnj_YFZj2g_pvZCM3C-AzDHfHYYZDQOJ4PWhWxYWu_-c-IF26uLzA</recordid><startdate>20020421</startdate><enddate>20020421</enddate><creator>Suk, Kyoungho</creator><creator>Kim, Sun Yeou</creator><creator>Leem, Kanghyun</creator><creator>Kim, Young Ock</creator><creator>Park, Sun Young</creator><creator>Hur, Jinyoung</creator><creator>Baek, Jihwoon</creator><creator>Lee, Kang Jin</creator><creator>Zheng, Hu Zhan</creator><creator>Kim, Hocheol</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020421</creationdate><title>Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats</title><author>Suk, Kyoungho ; Kim, Sun Yeou ; Leem, Kanghyun ; Kim, Young Ock ; Park, Sun Young ; Hur, Jinyoung ; Baek, Jihwoon ; Lee, Kang Jin ; Zheng, Hu Zhan ; Kim, Hocheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-5bab8e0cb95d64bf250dbc42de9dbf1ef1d459046097e729cc38005d40b566003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Blotting, Western</topic><topic>Cell Death - drug effects</topic><topic>Cell Line</topic><topic>Cyclooxygenase</topic><topic>Cyclooxygenase 2</topic><topic>Cyclooxygenase 2 Inhibitors</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Dinoprostone - biosynthesis</topic><topic>Dinoprostone - genetics</topic><topic>Hippocampus - pathology</topic><topic>Immunohistochemistry</topic><topic>Indicators and Reagents</topic><topic>Ischemia</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - pathology</topic><topic>Isoenzymes - metabolism</topic><topic>Mice</topic><topic>Neurons - drug effects</topic><topic>Neuroprotection</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide - metabolism</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots - chemistry</topic><topic>Plant Stems - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Rubiaceae - chemistry</topic><topic>TNF-α</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Uncaria rhynchophylla</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suk, Kyoungho</creatorcontrib><creatorcontrib>Kim, Sun Yeou</creatorcontrib><creatorcontrib>Leem, Kanghyun</creatorcontrib><creatorcontrib>Kim, Young Ock</creatorcontrib><creatorcontrib>Park, Sun Young</creatorcontrib><creatorcontrib>Hur, Jinyoung</creatorcontrib><creatorcontrib>Baek, Jihwoon</creatorcontrib><creatorcontrib>Lee, Kang Jin</creatorcontrib><creatorcontrib>Zheng, Hu Zhan</creatorcontrib><creatorcontrib>Kim, Hocheol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suk, Kyoungho</au><au>Kim, Sun Yeou</au><au>Leem, Kanghyun</au><au>Kim, Young Ock</au><au>Park, Sun Young</au><au>Hur, Jinyoung</au><au>Baek, Jihwoon</au><au>Lee, Kang Jin</au><au>Zheng, Hu Zhan</au><au>Kim, Hocheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2002-04-21</date><risdate>2002</risdate><volume>70</volume><issue>21</issue><spage>2467</spage><epage>2480</epage><pages>2467-2480</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>In traditional Oriental medicine,
Uncaria rhynchophylla has been used to lower blood pressure and to relieve various neurological symptoms. However, scientific evidence related to its effectiveness or precise modes of action has not been available. Thus, in the current study, we evaluated neuroprotective effects of
U. rhynchophylla after transient global ischemia using 4-vessel occlusion model in rats. Methanol extract of
U. rhynchophylla administered intraperitoneally (100–1000 mg/kg at 0 and 90 min after reperfusion) significantly protected hippocampal CA1 neurons against 10 min transient forebrain ischemia. Measurement of neuronal cell density in CA1 region at 7 days after ischemia by Nissl staining revealed more than 70% protection in
U. rhynchophylla-treated rats compared to saline-treated animals. In
U. rhynchophylla-treated animals, induction of cyclooxygenase-2 in hippocampus at 24 hr after ischemia was significantly inhibited at both mRNA and protein levels. Furthermore,
U. rhynchophylla extract inhibited TNF-α and nitric oxide production in BV-2 mouse microglial cells
in vitro. These anti-inflammatory actions of
U. rhynchophylla extract may contribute to its neuroprotective effects.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>12173411</pmid><doi>10.1016/S0024-3205(02)01534-5</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2002-04, Vol.70 (21), p.2467-2480 |
| issn | 0024-3205 1879-0631 |
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| source | ScienceDirect Journals |
| subjects | Animals Blotting, Western Cell Death - drug effects Cell Line Cyclooxygenase Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Dinoprostone - biosynthesis Dinoprostone - genetics Hippocampus - pathology Immunohistochemistry Indicators and Reagents Ischemia Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - pathology Isoenzymes - metabolism Mice Neurons - drug effects Neuroprotection Neuroprotective Agents - pharmacology Nitric Oxide - biosynthesis Nitric Oxide - metabolism Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction Rubiaceae - chemistry TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Uncaria rhynchophylla |
| title | Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats |
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