Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy

Background and aims Left ventricular (LV) dilation and myocardial remodelling are hallmarks of heart failure in idiopathic dilated cardiomyopathy (DCM). Interstitial collagen is essential for LV integrity and function while degradation of collagen by collagenases, especially matrix‐metalloproteinase...

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Bibliographic Details
Published in:European journal of heart failure 2002-08, Vol.4 (4), p.439-444
Main Authors: Schwartzkopff, Bodo, Fassbach, Michael, Pelzer, Beate, Brehm, Michael, Strauer, Bodo E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Cardiomyopathy, Dilated - diagnosis
Cardiomyopathy, Dilated - enzymology
Collagen - blood
collagenases
Collagenases - blood
dilated cardiomyopathy
Female
Heart Failure - diagnosis
Heart Failure - enzymology
Humans
LV dilation
Male
Matrix Metalloproteinase 1 - blood
Matrix Metalloproteinases - blood
matrix-metalloproteinases
Middle Aged
Myocardium - enzymology
Tissue Inhibitor of Metalloproteinase-1 - blood
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - enzymology
Ventricular Remodeling - physiology
ventricular remodelling
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Summary:Background and aims Left ventricular (LV) dilation and myocardial remodelling are hallmarks of heart failure in idiopathic dilated cardiomyopathy (DCM). Interstitial collagen is essential for LV integrity and function while degradation of collagen by collagenases, especially matrix‐metalloproteinases (MMPs), are suggested to contribute to ventricular dilation. In the present study, serological markers of collagen metabolism were investigated. Methods and results Serum levels of MMP‐1 and its inhibitor (TIMP‐1), the markers for collagen degradation type I (collagen carboxyterminal telopeptide (ICTP)) and synthesis (carboxyterminal propeptide of type I procollagen (PICP)) were quantified by ELISA and RIA of 43 patients with DCM and 47 age‐matched control subjects. Free MMP‐1 serum concentration was significantly increased in the DCM group (5.29±0.83 vs. 2.22±0.29 ng/ml; P‐0.01) as well as the free TIMP‐1 concentration (206.54±12.65 vs. 181.44±8.55 ng/ml; P‐0.05). The free MMP‐1/TIMP‐1‐ratio was higher in DCM than in the control group (0.030±0.005 vs. 0.012±0.001; P‐0.01). ICTP was significantly increased (7.60±1.21 vs. 3.44±0.19 μg/l; P
ISSN:1388-9842
1879-0844
DOI:10.1016/S1388-9842(02)00092-2