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Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents
Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protec...
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| Published in: | Burns 2002-08, Vol.28 (5), p.435-442 |
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| cites | cdi_FETCH-LOGICAL-c391t-97dccba5bfdc692ad27df6c0bfaf6c547754bbecbeed0afb0d9675a2071f8f903 |
| container_end_page | 442 |
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| container_title | Burns |
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| creator | Berlanga, Jorge Lodos, Jorge López-Saura, Pedro |
| description | Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protection to the gastric mucosa. We examined whether a single systemic intervention with EGF prevents organ systems damages, following full-thickness scalds (25–30%) in rodents. Animals were randomly assigned to receive an intraperitoneal injection of EGF (30
μg/kg in mice, 10
μg/kg in rats) or saline solution, 30
min prior thermal injury in mice or after the cutaneous injury in rats. General clinical condition and mortality during 24
h were recorded. Animals were autopsied and histopathological and histomorphometric studies were conducted. Mice treated with EGF exhibited a milder clinical evolution and acute lethality was significantly reduced as compared to saline counterparts (
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| doi_str_mv | 10.1016/S0305-4179(02)00023-2 |
| format | article |
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μg/kg in mice, 10
μg/kg in rats) or saline solution, 30
min prior thermal injury in mice or after the cutaneous injury in rats. General clinical condition and mortality during 24
h were recorded. Animals were autopsied and histopathological and histomorphometric studies were conducted. Mice treated with EGF exhibited a milder clinical evolution and acute lethality was significantly reduced as compared to saline counterparts (
P<0.01). Histopathological and morphometric analysis showed that EGF significantly reduced intestinal necrosis and contributed to preserve jejunoileal architecture in mice (
P<0.05) and rats (
P<0.01). The onset of renal hemorrhagic foci was significantly reduced in EGF-treated groups (
P<0.01). Lung damages appeared attenuated in EGF-treated animals. These data indicate the salutary effects of EGF by attenuating internal complications associated to thermal injuries. Further studies are warranted to fully elucidate the usefulness of this therapy.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/S0305-4179(02)00023-2</identifier><identifier>PMID: 12163282</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Burns ; Burns - complications ; Burns - pathology ; Cytoprotection ; Digestive System - drug effects ; Digestive System - pathology ; Disease Models, Animal ; Emergency and intensive care: burns ; Epidermal growth factor (EGF) ; Epidermal Growth Factor - administration & dosage ; Epidermal Growth Factor - therapeutic use ; Injections, Intraperitoneal ; Intensive care medicine ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Multiple Organ Failure - etiology ; Multiple Organ Failure - pathology ; Multiple Organ Failure - prevention & control ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Trauma Severity Indices</subject><ispartof>Burns, 2002-08, Vol.28 (5), p.435-442</ispartof><rights>2002 Elsevier Science Ltd and ISBI</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-97dccba5bfdc692ad27df6c0bfaf6c547754bbecbeed0afb0d9675a2071f8f903</citedby><cites>FETCH-LOGICAL-c391t-97dccba5bfdc692ad27df6c0bfaf6c547754bbecbeed0afb0d9675a2071f8f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13866742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12163282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berlanga, Jorge</creatorcontrib><creatorcontrib>Lodos, Jorge</creatorcontrib><creatorcontrib>López-Saura, Pedro</creatorcontrib><title>Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents</title><title>Burns</title><addtitle>Burns</addtitle><description>Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protection to the gastric mucosa. We examined whether a single systemic intervention with EGF prevents organ systems damages, following full-thickness scalds (25–30%) in rodents. Animals were randomly assigned to receive an intraperitoneal injection of EGF (30
μg/kg in mice, 10
μg/kg in rats) or saline solution, 30
min prior thermal injury in mice or after the cutaneous injury in rats. General clinical condition and mortality during 24
h were recorded. Animals were autopsied and histopathological and histomorphometric studies were conducted. Mice treated with EGF exhibited a milder clinical evolution and acute lethality was significantly reduced as compared to saline counterparts (
P<0.01). Histopathological and morphometric analysis showed that EGF significantly reduced intestinal necrosis and contributed to preserve jejunoileal architecture in mice (
P<0.05) and rats (
P<0.01). The onset of renal hemorrhagic foci was significantly reduced in EGF-treated groups (
P<0.01). Lung damages appeared attenuated in EGF-treated animals. These data indicate the salutary effects of EGF by attenuating internal complications associated to thermal injuries. Further studies are warranted to fully elucidate the usefulness of this therapy.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Burns - complications</subject><subject>Burns - pathology</subject><subject>Cytoprotection</subject><subject>Digestive System - drug effects</subject><subject>Digestive System - pathology</subject><subject>Disease Models, Animal</subject><subject>Emergency and intensive care: burns</subject><subject>Epidermal growth factor (EGF)</subject><subject>Epidermal Growth Factor - administration & dosage</subject><subject>Epidermal Growth Factor - therapeutic use</subject><subject>Injections, Intraperitoneal</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Multiple Organ Failure - etiology</subject><subject>Multiple Organ Failure - pathology</subject><subject>Multiple Organ Failure - prevention & control</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><subject>Trauma Severity Indices</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqF0LtuFDEUBmALgcgm4RFAboiSYsD2XDyuUBTlghSJAlJbvhwvRjP2xvYQ9u3xZlekpDrN959j_wi9p-QTJXT4_J20pG86ysU5YReEENY27BVa0ZGLhnZEvEarf-QIHef8qyLSj-QtOqKMDi0b2Qo9XpYCYVHFx4Cjwz4USEFNOKa1CtiqWa0hY73F8CeuIcQlT1us7OyDz5WCxbDxFtJcM-sUn8pP7JQpMeHz69ubi7oQ6yWF6lK0EEo-RW-cmjK8O8wT9HBz_ePqrrn_dvv16vK-Ma2gpRHcGqNVr501g2DKMm7dYIh2qo6-47zvtAajASxRThMrBt4rRjh1oxOkPUFn-72bFB8XyEXOPhuYJhWg_kJyKsah57TCfg9NijkncHKT_KzSVlIid13L567lrkhJmHzuWrKa-3A4sOgZ7EvqUG4FHw9AZaMml1QwPr-4dhwG3u3cl72DWsdvD0lm4yEYsD6BKdJG_5-n_AVHX54j</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>Berlanga, Jorge</creator><creator>Lodos, Jorge</creator><creator>López-Saura, Pedro</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents</title><author>Berlanga, Jorge ; Lodos, Jorge ; López-Saura, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-97dccba5bfdc692ad27df6c0bfaf6c547754bbecbeed0afb0d9675a2071f8f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Burns</topic><topic>Burns - complications</topic><topic>Burns - pathology</topic><topic>Cytoprotection</topic><topic>Digestive System - drug effects</topic><topic>Digestive System - pathology</topic><topic>Disease Models, Animal</topic><topic>Emergency and intensive care: burns</topic><topic>Epidermal growth factor (EGF)</topic><topic>Epidermal Growth Factor - administration & dosage</topic><topic>Epidermal Growth Factor - therapeutic use</topic><topic>Injections, Intraperitoneal</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Multiple Organ Failure - etiology</topic><topic>Multiple Organ Failure - pathology</topic><topic>Multiple Organ Failure - prevention & control</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Trauma Severity Indices</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berlanga, Jorge</creatorcontrib><creatorcontrib>Lodos, Jorge</creatorcontrib><creatorcontrib>López-Saura, Pedro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berlanga, Jorge</au><au>Lodos, Jorge</au><au>López-Saura, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>28</volume><issue>5</issue><spage>435</spage><epage>442</epage><pages>435-442</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protection to the gastric mucosa. We examined whether a single systemic intervention with EGF prevents organ systems damages, following full-thickness scalds (25–30%) in rodents. Animals were randomly assigned to receive an intraperitoneal injection of EGF (30
μg/kg in mice, 10
μg/kg in rats) or saline solution, 30
min prior thermal injury in mice or after the cutaneous injury in rats. General clinical condition and mortality during 24
h were recorded. Animals were autopsied and histopathological and histomorphometric studies were conducted. Mice treated with EGF exhibited a milder clinical evolution and acute lethality was significantly reduced as compared to saline counterparts (
P<0.01). Histopathological and morphometric analysis showed that EGF significantly reduced intestinal necrosis and contributed to preserve jejunoileal architecture in mice (
P<0.05) and rats (
P<0.01). The onset of renal hemorrhagic foci was significantly reduced in EGF-treated groups (
P<0.01). Lung damages appeared attenuated in EGF-treated animals. These data indicate the salutary effects of EGF by attenuating internal complications associated to thermal injuries. Further studies are warranted to fully elucidate the usefulness of this therapy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12163282</pmid><doi>10.1016/S0305-4179(02)00023-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Burns Burns - complications Burns - pathology Cytoprotection Digestive System - drug effects Digestive System - pathology Disease Models, Animal Emergency and intensive care: burns Epidermal growth factor (EGF) Epidermal Growth Factor - administration & dosage Epidermal Growth Factor - therapeutic use Injections, Intraperitoneal Intensive care medicine Male Medical sciences Mice Mice, Inbred BALB C Multiple Organ Failure - etiology Multiple Organ Failure - pathology Multiple Organ Failure - prevention & control Random Allocation Rats Rats, Sprague-Dawley Time Factors Trauma Severity Indices |
| title | Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents |
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