Glomerulonephritis with microtubular deposits associated with cryoglobulinemia and chronic active hepatitis

A 65‐year‐old‐woman presented with edema, ascites, proteinuria and abnormal liver function tests. A small amount of mixed cryoglobulin was detected in her serum. Liver biopsy revealed mild chronic active hepatitis, but tests for hepatotropic viral infection were negative. Electron microscopy of the...

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Bibliographic Details
Published in:Pathology international 2002-07, Vol.52 (7), p.483-487
Main Authors: Hirahashi, Junichi, Kuramochi, Shigeru, Konishi, Konosuke, Chikaraishi, Akihiro, Takase, Osamu, Hayashi, Matsuhiko, Saruta, Takao
Format: Article
Language:English
Subjects:
Aged
Biopsy
chronic active hepatitis
Cryoglobulinemia - complications
Cryoglobulinemia - metabolism
Cryoglobulinemia - pathology
Cryoglobulinemia - physiopathology
cryoglobulinemic glomerulonephritis
Female
glomerular organized deposits
Glomerulonephritis - complications
Glomerulonephritis - metabolism
Glomerulonephritis - pathology
Glomerulonephritis - physiopathology
Hepatitis, Chronic - complications
Hepatitis, Chronic - metabolism
Hepatitis, Chronic - pathology
Hepatitis, Chronic - physiopathology
Humans
Kidney Tubules - pathology
Kidney Tubules - ultrastructure
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Summary:A 65‐year‐old‐woman presented with edema, ascites, proteinuria and abnormal liver function tests. A small amount of mixed cryoglobulin was detected in her serum. Liver biopsy revealed mild chronic active hepatitis, but tests for hepatotropic viral infection were negative. Electron microscopy of the renal biopsy revealed glomerular electron‐dense deposits that contained numerous tubular structures. Renal amyloidosis and light chain deposition disease were ruled out by appropriate histological techniques. The ultrastructural findings of renal biopsy suggested either cryoglobulinemic glomerulonephritis or immunotactoid glomerulopathy. Although the exact interrelationship among the peculiar glomerulopathy, cryoglobulinemia and chronic active hepatitis in the present case remains undetermined, this report enlarges the spectrum of glomerulopathy characterized by extracellular deposition of microtubules.
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2002.01376.x