Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor

Extracellular Ca(2+) concentration [Ca(2+)](o) is vital for a number of processes varying from blood clotting to regulation membrane permeability and excitability. For this reason [Ca(2+)](o) is under strict control of a complex homeostatic system that includes parathyroid glands, kidneys, bones and...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2002-07, Vol.447 (2-3), p.271-278
Main Authors: McLarnon, Stuart J, Riccardi, Daniela
Format: Article
Language:English
Subjects:
Aniline Compounds - therapeutic use
Animals
Calcium - metabolism
Humans
Magnesium - metabolism
Osmolar Concentration
Phenethylamines
Propylamines
Receptors, Calcium-Sensing - agonists
Receptors, Calcium-Sensing - drug effects
Receptors, Calcium-Sensing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extracellular Ca(2+) concentration [Ca(2+)](o) is vital for a number of processes varying from blood clotting to regulation membrane permeability and excitability. For this reason [Ca(2+)](o) is under strict control of a complex homeostatic system that includes parathyroid glands, kidneys, bones and intestine. The extracellular Ca(2+)-sensing receptor is an essential component of this system, regulating parathyroid hormone secretion, Ca(2+) (and Mg(2+)) excretion by the kidney, bone remodeling and Ca(2+) reabsorption by the gastrointestinal tract. The Ca(2+)-sensing receptor is also present in organs without an obvious link with mineral ion metabolism. This review will describe the discovery of a novel class of ion-sensing receptor(s), receptor-effector coupling and the roles of the Ca(2+)-sensing receptor inside and outside the Ca(2+)(o) homeostatic system.
ISSN:0014-2999
DOI:10.1016/S0014-2999(02)01849-6