A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells

A novel method to include poorly water-soluble substances into the polyelectrolyte capsules of defined size, stability, composition and affinity properties is proposed. Encapsulation explores the polarity gradient across the capsule wall. Capsules creation makes use of electrostatic interaction and...

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Bibliographic Details
Published in:International journal of pharmaceutics 2002-08, Vol.242 (1), p.219-223
Main Authors: Radtchenko, Igor L, Sukhorukov, Gleb B, Möhwald, Helmuth
Format: Article
Language:English
Subjects:
Biocompatibility
Biological and medical sciences
Capsules
Drug Compounding - methods
Drug delivery systems
Electrolytes - chemistry
Encapsulation
General pharmacology
Layer-by-layer
Medical sciences
Microcapsules
Microscopy, Confocal
Microscopy, Electron, Scanning
Particle Size
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers
Polymers - chemistry
Polystyrenes - chemistry
Solubility
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Summary:A novel method to include poorly water-soluble substances into the polyelectrolyte capsules of defined size, stability, composition and affinity properties is proposed. Encapsulation explores the polarity gradient across the capsule wall. Capsules creation makes use of electrostatic interaction and can involve many substances as layer constituents, such as synthetic polyelectrolytes, proteins, nucleic acids, lipids and multivalent dyes. Using capsules made of synthetic polyelectrolytes as a model system was demonstrated how to prepare, to measure and to use this gradient for low molecular weigh materials encapsulation.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(02)00161-8