Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii

• Published in: Phytochemistry (Oxford) 2002-09, Vol.61 (2), p.171-174
• Main Authors: Ito, Aiko, Chai, Hee-Byung, Lee, Dongho, Kardono, Leonardus B.S, Riswan, Soedarsono, Farnsworth, Norman R, Cordell, Geoffrey A, Pezzuto, John M, Kinghorn, A.Douglas
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Chemical constitution; Cucurbitacins; Cytotoxicity; Elaeocarpaceae; Elaeocarpus mastersii; Ellagic Acid - analogs & derivatives; Ellagic Acid - isolation & purification; Ellagic Acid - pharmacology; Ellagic acid derivatives; Fundamental and applied biological sciences. Psychology; General pharmacology; Humans; Magnetic Resonance Spectroscopy; Magnoliopsida - chemistry; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Bark - chemistry; Plant physiology and development; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Tumor Cells, Cultured
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(02)00232-7

Bioassay-guided investigation of the bark of Elaeocarpus mastersii using KB (human oral epidermoid carcinoma) cells as a monitor led to the isolation of two cucurbitacins, cucurbitacin D and cucurbitacin F as cytotoxic principles, together with two ellagic acid derivatives, 4′- O-methylellagic acid 3-(2″,3″-di- O-acetyl)-α- l-rhamnoside ( 1) and 4,4′- O-dimethylellagic acid 3-(2″,3″-di- O-acetyl)-α- l-rhamnoside ( 2). These compounds were evaluated against a panel of human tumor cell lines. Bioassay-guided investigation of Elaeocarpus mastersii led to the isolation of cucurbitacins D and F as active principles, together with ellagic acid derivatives 1 and 2.