Assimilation of nitrate by yeasts

Abstract Nitrate assimilation has received much attention in filamentous fungi and plants but not so much in yeasts. Recently the availability of classical genetic and molecular biology tools for the yeast Hansenula polymorpha has allowed the advance of the study of this metabolic pathway in yeasts....

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Bibliographic Details
Published in:FEMS microbiology reviews 2002-08, Vol.26 (3), p.277-284
Main Author: Siverio, José M.
Format: Article
Language:English
Subjects:
Anion Transport Proteins
Assimilation
Biological and medical sciences
Biological assimilation
Fundamental and applied biological sciences. Psychology
Fungi
Gene expression
Gene Expression Regulation, Fungal
Gene regulation
Genes
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Hansenula polymorpha
Metabolic pathways
Microbiology
Molecular biology
Mycology
Nitrate and nitrite assimilation
Nitrate reductase
Nitrate Reductases - genetics
Nitrate transport
Nitrates
Nitrates - metabolism
Nitrite reductase
Nitrite Reductases - genetics
Nitrites - metabolism
Pichia - enzymology
Pichia - genetics
Pichia - metabolism
Pichia angusta
Reductases
Regulatory mechanisms (biology)
Signal transduction
Transcription factors
Transcription Factors - biosynthesis
Transcription Factors - genetics
Yeast
Yeasts
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Summary:Abstract Nitrate assimilation has received much attention in filamentous fungi and plants but not so much in yeasts. Recently the availability of classical genetic and molecular biology tools for the yeast Hansenula polymorpha has allowed the advance of the study of this metabolic pathway in yeasts. The genes YNT1, YNR1 and YNI1, encoding respectively nitrate transport, nitrate reductase and nitrite reductase, have been cloned, as well as two other genes encoding transcriptional regulatory factors. All these genes lie closely together in a cluster. Transcriptional regulation is the main regulatory mechanism that controls the levels of the enzymes involved in nitrate metabolism although other mechanisms may also be operative. The process involved in the sensing and signalling of the presence of nitrate in the medium is not well understood. In this article the current state of the studies of nitrate assimilation in yeasts as well as possible venues for future research are reviewed.
ISSN:0168-6445
1574-6976
1574-6976
DOI:10.1111/j.1574-6976.2002.tb00615.x