Beneficial effects of metoprolol on myocardial sympathetic function: Evidence from a randomized, placebo-controlled study in patients with congestive heart failure

We sought to investigate whether beta-blockers exert a presynaptic effect in the myocardium as measured by 123I-metaiodobenzylguanidine. The study comprised 59 patients with congestive heart failure, New York Heart Association class II or III, and left ventricular ejection fraction

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Bibliographic Details
Published in:The American heart journal 2002-08, Vol.144 (2), p.E3-E3
Main Authors: de Milliano, Paul A R, de Groot, Andre C, Tijssen, Jan G P, van Eck-Smit, Berthe L F, Van Zwieten, Pieter A, Lie, Kong I
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - pharmacokinetics
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - pharmacokinetics
Aged
Double-Blind Method
Down-Regulation
Female
Heart - drug effects
Heart - innervation
Heart Failure - diagnosis
Heart Failure - drug therapy
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Male
Metoprolol - administration & dosage
Metoprolol - pharmacokinetics
Middle Aged
Myocardium - metabolism
Presynaptic Terminals - drug effects
Radiopharmaceuticals
Tomography, Emission-Computed, Single-Photon
Online Access:Get full text
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Description
Summary:We sought to investigate whether beta-blockers exert a presynaptic effect in the myocardium as measured by 123I-metaiodobenzylguanidine. The study comprised 59 patients with congestive heart failure, New York Heart Association class II or III, and left ventricular ejection fraction
ISSN:1097-6744