Bone marrow biopsy in adult acute lymphoblastic leukemia: morphological characteristics and contribution to the study of prognostic factors

Bone marrow (BM) sections were examined in 128 untreated adult patients with newly diagnosed acute lymphoblastic leukemia (ALL), seen in our institution over a 19-year period. BM biopsy was performed in order to assess the incidence, degree and prognostic significance of histological data of the dis...

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Bibliographic Details
Published in:Leukemia research 2002-10, Vol.26 (10), p.909-918
Main Authors: Thomas, Xavier, Le, Quoc-Hung, Danaı̈la, Catalin, Lhéritier, Véronique, Ffrench, Martine
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Adult
Aged
Analysis of Variance
Biological and medical sciences
Biopsy
Bone Marrow - pathology
Bone marrow biopsy
Cytodiagnosis
Female
Fibrosis
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Retrospective Studies
Risk Factors
Survival Analysis
Treatment Outcome
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Summary:Bone marrow (BM) sections were examined in 128 untreated adult patients with newly diagnosed acute lymphoblastic leukemia (ALL), seen in our institution over a 19-year period. BM biopsy was performed in order to assess the incidence, degree and prognostic significance of histological data of the disease. BM features studied were reticular fibrosis, total cellularity, residual hematopoiesis, mitotic activity, and blastic infiltration. T-cell lineage ALL were diagnosed in 23% of the cases, while B-cell lineage ALL represented 70% of the cases. There were 7% of non-T-non-B-cell lineage ALL. The percentage of BM leukemic cells was related to cellularity ( P=0.02), while it was related to the disappearance of normal cell lines ( P
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(02)00034-6