Cerebral demyelination in Wegener’s granulomatosis

A 38-year-old woman with a history of a granulomatous lesion of the nose, developed blurred vision, ataxic gait, and spastic tetraparesis. The presence of demyelination on the brain MRI led to the diagnosis of cerebral demyelination associated with Wegener’s granulomatosis. Pulse cyclophosphamide ad...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2004-06, Vol.106 (3), p.233-236
Main Authors: Brinar, Vesna V, Cikes, Nada, Petelin, Zeljka, Hlavati, Marina, Poser, Charles M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - pathology
Demyelinating Diseases - complications
Demyelinating Diseases - pathology
Disseminated encephalomyelitis
Female
Granulomatosis with Polyangiitis - complications
Granulomatosis with Polyangiitis - pathology
Humans
Magnetic Resonance Imaging
Medical imaging
Medical sciences
Medical treatment
MRI
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - pathology
Neurology
Neurosurgery
Sarcoidosis
Sinuses
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Wegener granulomatosis
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Summary:A 38-year-old woman with a history of a granulomatous lesion of the nose, developed blurred vision, ataxic gait, and spastic tetraparesis. The presence of demyelination on the brain MRI led to the diagnosis of cerebral demyelination associated with Wegener’s granulomatosis. Pulse cyclophosphamide administration resulted in some clinical of improvement of her condition. Demyelinating lesions seen in Wegener’s have been ascribed to multiple sclerosis, but in this case, they are much more reminiscent of disseminated encephalomyelitis (DEM). The immunological challenge of the underlying disease, may, in the genetically susceptible person, presumably trigger the appearance of MS lesions. Wegener’s granulomatosis must be considered in the differential diagnosis of MS.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2004.02.021