Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: Evidence for a subclinical cardiomyopathy

The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BM...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2002-07, Vol.25 (7), p.590-597
Main Authors: ÖZBEY, N, SEZGIL, A, OFLAZ, H, UMMAN, B, ORHAN, Y, SENCER, E, MOLVALILAR, S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - analysis
Body Composition
Cardiomyopathies - diagnosis
Cardiomyopathies - etiology
Cholesterol, LDL - blood
Diastole
Electric Impedance
Endocrinopathies
Female
Human Growth Hormone - deficiency
Humans
Hypopituitarism - complications
Hypopituitarism - physiopathology
Hypothalamus. Hypophysis. Epiphysis (diseases)
Insulin-Like Growth Factor I - analysis
Lipids - blood
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Systole
Tropical medicine
Ultrasonography
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BMI matched healthy controls. Mean duration of hypopituitarism was 108.6 +/- 77.0 months. None of the patients and controls presented with or had previous diagnosis of concomitant diseases that could affect cardiac function. All hormone deficiencies, except for GH, were appropriately replaced in the patients. Left ventricular function and geometry were evaluated by two-dimensional, M-mode and Doppler echocardiography. Body composition was evaluated by bioelectrical impedance analysis. Not significant differences were observed with respect to left heart dimensions and left ventricular systolic function between patients and controls. Nevertheless 2 of the left ventricular diastolic function parameters, deceleration time and isovolumetric relaxation time, were significantly prolonged in the patients compared with controls (247.88 +/- 70.65 vs 143.26 +/- 31.70 milliseconds (ms) and 122.31 +/- 18.24 vs 89.47 +/- 12.12 ms respectively, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03345081