Antiulcerogenic activity of ethanol extract of Solanum variabile (false “jurubeba”)

• Published in: Journal of ethnopharmacology 2004-07, Vol.93 (1), p.83-88
• Main Authors: Antonio, J.M, Gracioso, J.S, Toma, W, Lopez, L.C, Oliveira, F, Souza Brito, A.R.M
• Format: Article
• Language: English
• Subjects: Animals; Anti-Ulcer Agents - isolation & purification; Anti-Ulcer Agents - therapeutic use; Biological and medical sciences; Chronic ulcer; Duodenal ulcer; Gastric ulcer; General pharmacology; Male; Medical sciences; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Components, Aerial; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Solanum; Solanum variabile; Stomach Ulcer - drug therapy; Stomach Ulcer - pathology
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2004.03.031

The ethanol extract (EE) of the aerial parts of Solanum variabile Mart. (Solanaceae) was investigated for its ability to prevent ulceration of the gastric and duodenal mucosa at different doses. Its ability to heal chronic ulcer processes was also evaluated. When the HCl/ethanol solution was used to induce gastric ulcer, the EE produced a significant dose-dependent reduction of lesion formation of 51, 74 and 89%, at doses of 250, 500 and 1000 mg/kg, respectively. The 100 mg/kg dose had no significant activity. The EE also significantly reduced the gastric lesions induced by the combination of indomethacin and bethanechol (60 and 72%) at doses of 500 and 1000 mg/kg and also reduced stress-induced gastric ulcer (41%) but only at the doses of 1000 mg/g ( P