Clinical significance of IL-18 gene over-expression in AML

Little is known about the clinical significance of interleukin (IL)-18, a novel immunoregulatory cytokine, in acute myeloid leukemia (AML). Using reverse transcriptase polymerase chain reaction (RT-PCR) analysis, levels of IL-18 mRNA were assessed in bone marrow mononuclear cells (BMMC) from 47 adul...

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Bibliographic Details
Published in:Leukemia research 2002-10, Vol.26 (10), p.887-892
Main Authors: Zhang, Bin, Wang, Yong, Zheng, Guo-Guang, Ma, Xiao-Tong, Li, Ge, Zhang, Feng-Kui, Wu, Ke-Fu
Format: Article
Language:English
Subjects:
Acute Disease
Acute myeloid leukemia
Adult
Biological and medical sciences
Bone Marrow - pathology
Case-Control Studies
Female
Gene Expression
Hematologic and hematopoietic diseases
Humans
Interleukin-18
Interleukin-18 - genetics
Leukemia, Myeloid - genetics
Leukemia, Myeloid - metabolism
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocyte Count
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - pathology
Male
Medical sciences
Middle Aged
Polymerase Chain Reaction
Prognosis
Prognostic factor
Risk Factors
RNA, Messenger - metabolism
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Summary:Little is known about the clinical significance of interleukin (IL)-18, a novel immunoregulatory cytokine, in acute myeloid leukemia (AML). Using reverse transcriptase polymerase chain reaction (RT-PCR) analysis, levels of IL-18 mRNA were assessed in bone marrow mononuclear cells (BMMC) from 47 adult patients with de novo or CR AML in order to explore the clinical significance of IL-18. The relationship between expression levels and the established prognostic factors such as age, cytogenetic aberrations, CD34 expression and FAB subtypes was investigated. Either disease status, age or CD34 expression were found to significantly correlate with the expression of IL-18. With respect to FAB cytotypes, expression of IL-18 gene in M4/M5 ( n=15) was statistically higher than that in other subtypes ( n=32, P
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(02)00025-5