Parallel and combinatorial approaches for synthesis of ligands

Although new detection screening methods must still be developed, the actual main limitation in combinatorial chemistry seems to be the diversity of ligands that can be generated in terms of real structural and chemical diversity. Thus, there is a strong interest for the development of different str...

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Bibliographic Details
Published in:Current opinion in chemical biology 2004-06, Vol.8 (3), p.311-318
Main Authors: Lavastre, Olivier, Bonnette, Fabien, Gallard, Laurent
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques - methods
Drug Design
Ligands
Models, Chemical
Oxazoles - chemical synthesis
Peptides - chemical synthesis
Pyridines - chemical synthesis
Thiazoles - chemical synthesis
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Summary:Although new detection screening methods must still be developed, the actual main limitation in combinatorial chemistry seems to be the diversity of ligands that can be generated in terms of real structural and chemical diversity. Thus, there is a strong interest for the development of different strategies for the parallel or combinatorial synthesis of ligands. We report here a selection of recent attempts proposing ‘open’ approaches able to increase the diversity of molecular architecture truly accessible via parallel or combinatorial processes.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.04.006