The role of free oxygen radicals on the development of otitis media with effusion

Objective: The purpose of this study was to determine if free oxygen radicals (FORs) and antioxidant enzyme activities have some role in pathogenesis of otitis media with effusion (OME) in children with adenoid hyperplasia. Methods: Seventy-four patients were enrolled in three groups of this study....

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Published in:International journal of pediatric otorhinolaryngology 2004-07, Vol.68 (7), p.889-894
Main Authors: Yariktas, Murat, Doner, Fehmi, Dogru, Harun, Yasan, Hasan, Delibas, Namik
Format: Article
Language:English
Subjects:
Adenoidectomy - statistics & numerical data
Adolescent
Ascorbic Acid - therapeutic use
Catalase - metabolism
Child
Child, Preschool
Effusion
Erythrocytes - metabolism
Female
Free oxygen radicals
Free Radicals - metabolism
Glutathione Peroxidase - metabolism
Humans
Male
Malondialdehyde - metabolism
Otitis media
Otitis Media with Effusion - drug therapy
Otitis Media with Effusion - epidemiology
Otitis Media with Effusion - metabolism
Reactive Oxygen Species - metabolism
Superoxide Dismutase - metabolism
Tonsillectomy - statistics & numerical data
Vitamin E - therapeutic use
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Summary:Objective: The purpose of this study was to determine if free oxygen radicals (FORs) and antioxidant enzyme activities have some role in pathogenesis of otitis media with effusion (OME) in children with adenoid hyperplasia. Methods: Seventy-four patients were enrolled in three groups of this study. The study group (Group I) included 26 patients who had adenoidectomy with ventilation tube placement due to chronic OME. The control adenoid group (Group II) consisted of 28 age-matched patients who had adenoidectomy without ventilation tube insertion. Twenty children were included in the healthy control group (Group III). Erythrocyte malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities were investigated in the venous blood sample. Results: Erythrocyte MDA level and GSH-Px enzyme activity in the blood samples of study group (Group I) were significantly higher than those of Group II and Group III ( P
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2004.02.002