Soy isoflavones prevent the ovarian hormone deficiency-associated rise in leukocytes in rats

Recent reports indicate that ovariectomy (ovx) increases lymphopoiesis. Ipriflavone, a synthetic isoflavone, has been reported to reduce lymphocytes in postmenopausal women. The aim of this study was to investigate whether naturally occurring isoflavones also affect lymphopoiesis in ovarian hormone...

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Published in:Phytomedicine (Stuttgart) 2004, Vol.11 (4), p.303-308
Main Authors: Soung, D.Y., Khalil, D.A., Arquitt, A.B., Smith, B.J., Hammond, L.J., Droke, E.A., Lucas, E.A., Devareddy, L., Arjmandi, B.H.
Format: Article
Language:English
Subjects:
Animals
Care and treatment
Diet
Estradiol - deficiency
Female
Glycine max
Health aspects
hematopoiesis
ipriflavone
Isoflavones
Isoflavones - administration & dosage
Isoflavones - pharmacology
Isoflavones - therapeutic use
Leukocyte Count
Leukocytes - drug effects
lymphocytes
Lymphocytopenia
Ovarian diseases
Ovariectomy
Phytotherapy
Postmenopausal women
Prevention
Rats
Rats, Sprague-Dawley
Soyfoods
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Summary:Recent reports indicate that ovariectomy (ovx) increases lymphopoiesis. Ipriflavone, a synthetic isoflavone, has been reported to reduce lymphocytes in postmenopausal women. The aim of this study was to investigate whether naturally occurring isoflavones also affect lymphopoiesis in ovarian hormone deficiency. The present study was carried out using an ovariectomized (ovx) rat model. To mimic early menopause, forty-eight 12-month-old Sprague-Dawley rats were either sham-operated (sham; 1 group) or ovx (3 groups) and were fed a standard semi-purified diet for 120 days. Thereafter, the ovx groups received one of the three doses of isoflavones: 0 (ovx), 500 (ISO500), or 1000 (ISO1000) mg/kg diet for 100 days. Ovariectomy increased total leukocyte counts significantly (p < 0.05) as a result of increased (p < 0.05) lymphocyte, monocyte, eosinophil, and basophil differential counts. Isoflavones at 500 and 1000 mg/kg diet returned the total leukocyte counts, as well as leukocyte subpopulations, to levels comparable to that of sham-operated rats. No other hematological parameters, e.g., red blood cell counts or red cell indices, were affected by ovariectomy or isoflavones. We conclude that soy isoflavones restore normal leukocyte counts elevated in ovarian hormone deficiency.
ISSN:0944-7113
1618-095X
DOI:10.1078/0944711041495164