Amelioration of Relapsing Polychondritis in a Child Treated with Oral Collagen

Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a rol...

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Bibliographic Details
Published in:The American journal of the medical sciences 2002-08, Vol.324 (2), p.101-103
Main Authors: Navarro, M.J., Higgins, G.C., Lohr, K.M., Myers, L.K.
Format: Article
Language:English
Subjects:
Administration, Oral
Autoimmunity
Biological and medical sciences
Child
Collagen Type II - administration & dosage
Collagen Type II - immunology
Cytokines
Cytokines - metabolism
Diseases of the osteoarticular system
Enzyme-Linked Immunosorbent Assay
Female
Humans
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Oral tolerance
Polychondritis, Relapsing - drug therapy
Polychondritis, Relapsing - immunology
Procollagen - administration & dosage
Procollagen - immunology
Relapsing polychondritis
T-Lymphocytes - immunology
Treatment Outcome
Type II collagen
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Summary:Relapsing polychondritis (RP) is a disease characterized by inflammation and the destruction of cartilage. The detection of antibodies to native type II collagen (CII) in the sera of some patients with relapsing polychondritis suggests that autoimmunity to this cartilage specific protein plays a role in the pathogenesis of the disease. RP is so rare that controlled therapeutic trials have not been carried out. We describe herein a child with RP who had amelioration of symptoms and a deviation in the cellular immune response to CII after being treated with daily oral CII as a toleragen.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200208000-00009