In vivo assessment of blood-spinal cord barrier permeability: serial dynamic contrast enhanced MRI of spinal cord injury

Serial in vivo dynamic contrast enhanced (DCE) MRI studies were performed on spinal cord injured rats on post-injury Days 0, 10, 20 and 30 to determine the distribution of gadopentetate-dimeglumine (Gd) concentration in injured cord tissue. A two-compartment pharmacokinetic model was fitted to the t...

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Bibliographic Details
Published in:Magnetic resonance imaging 2002-05, Vol.20 (4), p.337-341
Main Authors: BILGEN, Mehmet, DOGAN, Bulent, NARAYANA, Ponnada A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Contrast Media
Gadolinium DTPA
Injuries of the nervous system and the skull. Diseases due to physical agents
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system
Permeability
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Rats
Rats, Sprague-Dawley
Spinal Cord - metabolism
Spinal Cord Injuries - diagnosis
Traumas. Diseases due to physical agents
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Summary:Serial in vivo dynamic contrast enhanced (DCE) MRI studies were performed on spinal cord injured rats on post-injury Days 0, 10, 20 and 30 to determine the distribution of gadopentetate-dimeglumine (Gd) concentration in injured cord tissue. A two-compartment pharmacokinetic model was fitted to the time course of the concentration data at the epicenter of injury for each post-injury day. From these fits, the rates of the Gd transport between plasma and injured cord tissue were determined as a measure of blood-spinal cord barrier (BSCB) permeability. The results indicated that Gd transport rates decrease steadily with a concomitant improvement in motor functions of the rats with post-injury time. Specifically, the rates of Gd accumulation in injured SC tissue and its clearance correlated with the neurobehavioral scores with correlation coefficients of rho = -0.96 and -0.79, respectively, suggesting a significant link between the neurobehavioral function and the restoration of BSCB integrity as a result of the ongoing repair and recovery processes within the injured cords.
ISSN:0730-725X
1873-5894
DOI:10.1016/s0730-725x(02)00504-0