Incomplete Correlation of Serum Vibriocidal Antibody Titer with Protection from Vibrio cholerae Infection in Urban Bangladesh

The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence ofVibrio cholerae 0139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic sett...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-06, Vol.189 (12), p.2318-2322
Main Authors: Saha, Debasish, LaRocque, Regina C., Khan, Ashraful I., Harris, Jason B., Begum, Yasmin Ara, Akramuzzaman, Syed M., Faruque, Edward T., Ryan, Edward T., Qadri, Firdausi, Calderwood, Stephen B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Bacterial - blood
Bacteria
Bacteriology
Bangladesh - epidemiology
Biological and medical sciences
Cholera
Cholera - epidemiology
Cholera - immunology
Cholera - microbiology
Colonic diseases
Diarrhea
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunity
Infant
Infections
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
Pandemics
Prospective Studies
Urban Population
Vibrio cholerae
Vibrio cholerae O1 - immunology
Vibrio cholerae O139 - immunology
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Summary:The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence ofVibrio cholerae 0139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection fromV cholerae Ol, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection fromV cholerae 0139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection fromV cholerae infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/421275