A Simple Approach to Sensor Discovery and Fabrication on Self-Assembled Monolayers on Glass

Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-06, Vol.126 (23), p.7293-7299
Main Authors: Basabe-Desmonts, Lourdes, Beld, Joris, Zimmerman, Rebecca S, Hernando, Jordi, Mela, Petra, García Parajó, María F, van Hulst, Niek F, van den Berg, Albert, Reinhoudt, David N, Crego-Calama, Mercedes
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Exact sciences and technology
General, instrumentation
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Summary:Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (μCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja049901o