Chromosome 22q11.2 microdeletion in a patient with hemophilia A

We report a 6-year-old patient with hemophilia A, who also exhibited clinical features typical of 22q11.2 deletion syndrome (22qDS). The specific traits were mild mental retardation, speech delay, hypernasal speech, deficits in voice quality and articulation, narrow palpebral fissures, broad and dep...

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Bibliographic Details
Published in:Annales de génétique 2004-04, Vol.47 (2), p.181-184
Main Authors: Derbent, Murat, Özbek, Namık, Alehan, Füsun, Yılmaz, Zerrin
Format: Article
Language:English
Subjects:
22q11.2
Biological and medical sciences
Bone Diseases - genetics
Child
Chromosomes, Human, Pair 2 - genetics
General aspects. Genetic counseling
Heart Defects, Congenital - genetics
Hemophilia A
Hemophilia A - genetics
Humans
Intellectual Disability - genetics
Language Development Disorders - genetics
Male
Medical genetics
Medical sciences
Mental retardation
Microdeletion
Syndrome
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Summary:We report a 6-year-old patient with hemophilia A, who also exhibited clinical features typical of 22q11.2 deletion syndrome (22qDS). The specific traits were mild mental retardation, speech delay, hypernasal speech, deficits in voice quality and articulation, narrow palpebral fissures, broad and depressed nasal root, high-arched palate, microstomia, and overfolded ears. The patient had no associated congenital cardiac or palatal malformations. It can be particularly difficult to identify this syndrome in newborns and infants without congenital heart defects. This case underlines that microdeletion of chromosome 22q11.2 should be considered in any patient who exhibits typical clinical features of 22qDS, regardless of whether they have another single-gene disorder.
ISSN:0003-3995
DOI:10.1016/j.anngen.2003.11.001