An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)

Polyporus Sclerotium (猪苓), botanically from the Polyporus umbellatus (PERS.) FRIES, was traditionally used for the purpose of promoting diuresis. The present study investigated the diuretic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to the chemical ass...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2004, Vol.27(6), pp.867-870
Main Authors: Yuan, Dan, Mori, Junna, Komatsu, Ken-ich, Makino, Toshiaki, Kano, Yoshihiro
Format: Article
Language:English
Subjects:
Animals
Cholestenones - pharmacology
diuresis
Diuresis - drug effects
Diuresis - physiology
Diuretics - isolation & purification
Diuretics - pharmacology
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
ergosta-4,6,8,22-tetraen-3-one (ergone)
Male
marker component
Mineralocorticoid Receptor Antagonists - isolation & purification
Mineralocorticoid Receptor Antagonists - pharmacology
Polyporaceae
Polyporus Sclerotium
Rats
Rats, Wistar
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Summary:Polyporus Sclerotium (猪苓), botanically from the Polyporus umbellatus (PERS.) FRIES, was traditionally used for the purpose of promoting diuresis. The present study investigated the diuretic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to the chemical assay for its quality standardization. It resulted in a reversion to ordinary value of the urinary ratio of Na/K in deoxycoricosterone acetate (DOCA)-treated and adrenalectomized rats, although it had no this effect on the Na or K contents as well as Na/K value both in normal rats and in adrenalectomized rats without DOCA. These data indicate that ergone possesses an anti-aldosteronic diuretic effect. Moreover, it was identified in the blood and bile of rats after its administration to the gastrointestinal tract. The above results demonstrate that it is an active component of Polyporus Sclerotium.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.27.867