Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance potential role of lamivudine

Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional imm...

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Published in:Digestive diseases and sciences 2002-08, Vol.47 (8), p.1782-1785
Main Authors: BOZKAYA, Hakan, YURDAYDIN, Cihan, TÖRÜNER, Murat, ARAT, Mutlu, BOZDAYI, A. Mithat, EREKUL, Selim, CINAR, Kubilay, KOC, Haluk, UZUNALIMOGLU, Özden
Format: Article
Language:English
Subjects:
Adult
Anemia, Aplastic - etiology
Antiviral Agents - therapeutic use
Biological and medical sciences
Hematology
Hepatitis B - complications
Hepatitis B - drug therapy
Hepatitis B - virology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lamivudine - therapeutic use
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Remission, Spontaneous
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container_end_page 1785
container_issue 8
container_start_page 1782
container_title Digestive diseases and sciences
container_volume 47
creator BOZKAYA, Hakan
YURDAYDIN, Cihan
TÖRÜNER, Murat
ARAT, Mutlu
BOZDAYI, A. Mithat
EREKUL, Selim
CINAR, Kubilay
KOC, Haluk
UZUNALIMOGLU, Özden
description Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive treatment but went into complete clinical remission after clearance of the hepatitis B virus. Disappearance of the hepatitis B virus occurred during lamivudine treatment and coincided with immune activation secondary to discontinuation of immunosuppressive therapy. This case was somewhat atypical in that a history of acute hepatitis preceding the aplastic anemia was absent. The observation made in this case report supports a cause-effect relationship between hepatitis B virus infection and aplastic anemia.
doi_str_mv 10.1023/A:1016444611997
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identifier ISSN: 0163-2116
ispartof Digestive diseases and sciences, 2002-08, Vol.47 (8), p.1782-1785
issn 0163-2116
1573-2568
language eng
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subjects Adult
Anemia, Aplastic - etiology
Antiviral Agents - therapeutic use
Biological and medical sciences
Hematology
Hepatitis B - complications
Hepatitis B - drug therapy
Hepatitis B - virology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lamivudine - therapeutic use
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Remission, Spontaneous
title Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance potential role of lamivudine
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