Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain

The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly, various centrally mediated effects of urotensin-II on behaviour, neuroendocrine hormones and neurochemistry have been described. To investigate...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2004-06, Vol.493 (1), p.95-98
Main Authors: Gartlon, Jane E., Ashmeade, Tracey, Duxon, Mark, Hagan, Jim J., Jones, Declan N.C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
c- fos
Dose-Response Relationship, Drug
Gene Expression - drug effects
Gene Expression - genetics
GPR14
Gyrus Cinguli - drug effects
Gyrus Cinguli - physiology
Injections, Intraventricular
Ligands
Male
Medical sciences
Midline Thalamic Nuclei - drug effects
Midline Thalamic Nuclei - physiology
Neuropeptides - chemistry
Neuropeptides - pharmacology
Periaqueductal Gray - drug effects
Periaqueductal Gray - physiology
Pharmacology. Drug treatments
Proto-Oncogene Proteins c-fos - genetics
Proto-Oncogene Proteins c-fos - immunology
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled - drug effects
Receptors, G-Protein-Coupled - physiology
United Kingdom
Urotensin-II
Urotensins - chemistry
Urotensins - pharmacology
UT receptor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly, various centrally mediated effects of urotensin-II on behaviour, neuroendocrine hormones and neurochemistry have been described. To investigate neuroanatomical substrates for the central actions of urotensin-II, expression of the immediate early gene c- fos was examined following intracerebroventricular administration to rats. Urotensin-II increased Fos expression in the cingulate cortex and periaqueductal grey, suggesting important central roles for urotensin-II and its receptor.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.04.009