Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The mechanism by which IgG reaches luminal secretions and the function of IgG in these locations are unknown. Here, we find that the human neonatal Fc receptor (FcRn) is the vehic...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2004-06, Vol.20 (6), p.769-783
Main Authors: Yoshida, Masaru, Claypool, Steven M, Wagner, Jessica S, Mizoguchi, Emiko, Mizoguchi, Atsushi, Roopenian, Derry C, Lencer, Wayne I, Blumberg, Richard S
Format: Article
Language:English
Subjects:
Adoptive Transfer
Animals
Antigen Presentation
Antigen-Antibody Complex - immunology
Antigen-Antibody Complex - metabolism
Antigens - immunology
Antigens - metabolism
beta 2-Microglobulin - immunology
CD4-Positive T-Lymphocytes - immunology
Cell Polarity
Cells, Cultured
Dendritic Cells - cytology
Dendritic Cells - immunology
Dogs
Endocytosis
Histocompatibility Antigens Class I
Humans
Hypotheses
Immunoglobulin G - immunology
Immunoglobulin G - metabolism
Intestines - cytology
Intestines - immunology
Intestines - metabolism
Lymphocytes
Mice
Mice, Transgenic
Ovalbumin - immunology
Ovalbumin - metabolism
Protein Transport
Rabbits
Receptors, Fc - genetics
Receptors, Fc - immunology
Receptors, Fc - metabolism
Rodents
Scholarships & fellowships
Small intestine
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Summary:Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain significant quantities of IgG. The mechanism by which IgG reaches luminal secretions and the function of IgG in these locations are unknown. Here, we find that the human neonatal Fc receptor (FcRn) is the vehicle that transports IgG across the intestinal epithelial barrier into the lumen where the IgG can bind cognate antigen. The FcRn can then recycle the IgG/antigen complex back across the intestinal barrier into the lamina propria for processing by dendritic cells and presentation to CD4(+) T cells in regional organized lymphoid structures. These results explain how IgG is secreted onto mucosal surfaces and scavenges luminal antigens for recognition by the immune system.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2004.05.007