The genetics and pathophysiology of diabetes mellitus type II

Type II diabetes is a common, complex and heterogeneous group of disorders of growing public health concern. Paradoxically, rare monogenic forms of diabetes mellitus have been the most informative regarding diabetes pathophysiology to date. We discuss disappointing results of genetic approaches thus...

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Bibliographic Details
Published in:Journal of inherited metabolic disease 2004-01, Vol.27 (3), p.331-347
Main Authors: Jenkins, A. B., Campbell, L. V.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - physiopathology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Humans
Molecular and cellular biology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Type II diabetes is a common, complex and heterogeneous group of disorders of growing public health concern. Paradoxically, rare monogenic forms of diabetes mellitus have been the most informative regarding diabetes pathophysiology to date. We discuss disappointing results of genetic approaches thus far, emphasizing the genetic heterogeneity underlying the common phenotypic endpoint of elevated blood glucose level and the phenotypic misclassification in large studies resulting from this admixture and from the obligatory use of epidemiological or clinical surrogate measures. We suggest that novel approaches that take explicit account of the phenotypic, environmental and genetic complexities of type II diabetes are needed and discuss some principles that might underlie such approaches.
ISSN:0141-8955
1573-2665
DOI:10.1023/B:BOLI.0000031097.31587.81