Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection

Although extracellular heat-shock protein 70 (Hsp70) potentially mediates an inflammatory response, the association of circulating Hsp70 with complications after surgery is poorly understood. Perioperative plasma concentrations of Hsp70 and interleukin-6 were measured by immunoassays in 64 consecuti...

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Bibliographic Details
Published in:The American journal of surgery 2004-06, Vol.187 (6), p.777-784
Main Authors: Kimura, Fumio, Itoh, Hiroshi, Ambiru, Satoshi, Shimizu, Hiroaki, Togawa, Akira, Yoshidome, Hiroyuki, Ohtsuka, Masayuki, Shimamura, Fumihiko, Kato, Atsushi, Nukui, Yuji, Miyazaki, Masaru
Format: Article
Language:English
Subjects:
Aged
Bile
Biological and medical sciences
Blood Loss, Surgical
Cancer
Cytokines
Embolisms
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Heat shock proteins
Heat-shock protein 70
Hepatectomy
HSP70 Heat-Shock Proteins - blood
Humans
Infection - blood
Infection - physiopathology
Infections
Inflammatory response
Interleukin-6
Interleukin-6 - blood
Ischemia
Length of Stay - statistics & numerical data
Logistic Models
Male
Medical sciences
Middle Aged
Morbidity
Mortality
Organ failure
Ostomy
Partial hepatectomy
Pathogenesis
Pneumonia
Postoperative Complications - blood
Postoperative Complications - physiopathology
Postoperative infection
Protein folding
Respiratory distress syndrome
Respiratory system
Rodents
Surgery
Time Factors
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Description
Summary:Although extracellular heat-shock protein 70 (Hsp70) potentially mediates an inflammatory response, the association of circulating Hsp70 with complications after surgery is poorly understood. Perioperative plasma concentrations of Hsp70 and interleukin-6 were measured by immunoassays in 64 consecutive patients undergoing liver resection. Plasma concentrations of Hsp70 and interleukin-6 showed a striking increase immediately after surgery, and on postoperative day 1. The Hsp70 levels correlated significantly with operation time, hepatic ischemia time, postoperative alanine aminotransferase levels, and maximum interleukin-6 levels ( P
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2003.08.029