Cognition and behavior at school entry in children with congenital hypothyroidism treated early with high-dose levothyroxine

To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per...

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Bibliographic Details
Published in:The Journal of pediatrics 2004-06, Vol.144 (6), p.747-752
Main Authors: SIMONFAU-ROY, J, MARTI, S, DEAL, C, HUOT, C, ROBAEY, P, VAN VLIET, Guy
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Child Behavior Disorders - epidemiology
Child Behavior Disorders - prevention & control
Child, Preschool
Cognition - drug effects
Congenital Hypothyroidism
Developmental Disabilities - epidemiology
Developmental Disabilities - prevention & control
Dose-Response Relationship, Drug
Endocrinopathies
Female
General aspects
Humans
Hypothyroidism - drug therapy
Infant, Newborn
Male
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Prospective Studies
Quebec - epidemiology
Severity of Illness Index
Statistics, Nonparametric
Thyroid. Thyroid axis (diseases)
Thyroxine - administration & dosage
Thyroxine - pharmacology
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Summary:To document cognition and behavior at school entry in these patients. Study design Eighteen children with congenital hypothyroidism (CH; 9 severe and 9 moderate, based on a surface of the knee epiphyses at diagnosis or=0.05 cm(2)) treated from a median of 14 days with a median of 12.0 microg/kg per day of levothyroxine were evaluated at 5 years, 9 months, with the McCarthy Scale and the Questionnaire for Evaluation of Social Behavior, as were 40 control children. The global IQs at 5 years, 9 months, were similar: medians (range) were 102 (87 to 133), 102 (84 to 135), and 115 (88 to 136) (not significant) for severe CH, moderate CH, and control children, respectively. The behavioral scores of CH children were within the normal range. However, the number of times when plasma TSH was >6.0 mIU/L during treatment was correlated positively with anxiety (P=.02) and inattention (P=.05), whereas the number of times TSH was
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(04)00142-8