Unexplained acute renal failure in a toddler: a rare complication of Epstein-Barr virus

A previously healthy toddler developed severe acute renal failure with nephromegaly and peripheral atypical lymphocytosis. Profound interstitial nephritis with acute tubular necrosis was diagnosed by renal biopsy, and both the clinical picture and serological evaluation suggested Epstein-Barr virus...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2002-08, Vol.17 (8), p.628-632
Main Authors: NORWOOD, Victoria F, STURGILL, Benjamin C
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Acute Kidney Injury - pathology
Antigens, Viral - analysis
Biological and medical sciences
Biopsy
Child, Preschool
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Herpesvirus 4, Human - immunology
Human viral diseases
Humans
Immunoenzyme Techniques
Infectious diseases
Kidney - pathology
Kidney Function Tests
Kidney Tubular Necrosis, Acute - pathology
Leukemic Infiltration - pathology
Male
Medical sciences
Nephritis, Interstitial - etiology
Nephritis, Interstitial - pathology
Viral diseases
Viral diseases of the genital and urinary system
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Summary:A previously healthy toddler developed severe acute renal failure with nephromegaly and peripheral atypical lymphocytosis. Profound interstitial nephritis with acute tubular necrosis was diagnosed by renal biopsy, and both the clinical picture and serological evaluation suggested Epstein-Barr virus (EBV) as the etiological agent. The previous reports of EBV-induced renal failure and the clinical and pathological presentations of interstitial nephritis in children are reviewed.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-002-0917-z