Oleamide and anandamide effects on food intake and sexual behavior of rats

Oleamide is a lipid with diverse properties, including cannabinoid-like activity. For example, it induces the classic triad of effects attributable to these molecules: decrease in core temperature, hypolocomotion, and reduction in pain perception. However, as it binds to the cannabinoid receptors (C...

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Bibliographic Details
Published in:Neuroscience letters 2004-06, Vol.364 (1), p.1-6
Main Authors: Martı́nez-González, Dolores, Bonilla-Jaime, Herlinda, Morales-Otal, Adriana, Henriksen, Steven J., Velázquez-Moctezuma, Javier, Prospéro-Garcı́a, Oscar
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acids - pharmacology
Biological and medical sciences
Cannabinoid Receptor Modulators - pharmacology
Dose-Response Relationship, Drug
Eating - drug effects
Endocannabinoids
Food intake
Fundamental and applied biological sciences. Psychology
Hypnotics and Sedatives - pharmacology
Lipids
Male
Marijuana
Oleic Acids - pharmacology
Polyunsaturated Alkamides
Rats
Rats, Wistar
Sexual behavior
Sexual Behavior - drug effects
Vertebrates: nervous system and sense organs
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Summary:Oleamide is a lipid with diverse properties, including cannabinoid-like activity. For example, it induces the classic triad of effects attributable to these molecules: decrease in core temperature, hypolocomotion, and reduction in pain perception. However, as it binds to the cannabinoid receptors (CB1) only at high concentrations, it is not considered an actual endocannabinoid. In this study, we tested the effect of oleamide on food intake and sexual behavior and compared it to the effect induced by anandamide. Results indicate that oleamide and anandamide increased food intake during the 3 h post-injection. In addition, anandamide but not oleamide induced changes in sexual performance. This study further supports the role of endocannabinoids in food ingestion and male sexual behavior and gives additional support to the notion that, although oleamide might not be an endocannabinoid, it shares some effects with them.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2004.03.080