Calcium/calmodulin-dependent protein kinase II and synaptic plasticity

A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation of excitatory synaptic transmission was proposed two decades ago when it was identified as a major postsynaptic density protein. Since then, fascinating mechanisms optimized to fine-tune the magnitude and loca...

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Bibliographic Details
Published in:Current opinion in neurobiology 2004-06, Vol.14 (3), p.318-327
Main Authors: Colbran, Roger J, Brown, Abigail M
Format: Article
Language:English
Subjects:
Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Cell Differentiation - physiology
Central Nervous System - cytology
Central Nervous System - enzymology
Dendrites - enzymology
Dendrites - ultrastructure
Humans
Memory - physiology
Neuronal Plasticity - physiology
Synapses - enzymology
Synapses - ultrastructure
Synaptic Membranes - enzymology
Synaptic Membranes - ultrastructure
Synaptic Transmission - physiology
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Summary:A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation of excitatory synaptic transmission was proposed two decades ago when it was identified as a major postsynaptic density protein. Since then, fascinating mechanisms optimized to fine-tune the magnitude and locations of CaMKII activity have been revealed. The importance of CaMKII activity and autophosphorylation to synaptic plasticity in vitro, and to a variety of learning and memory paradigms in vivo has been demonstrated. Recent progress brings us closer to understanding the regulation of dendritic CaMKII activity, localization, and expression, and its role in modulating synaptic transmission and cell morphology.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2004.05.008