Effect of d-serine on a delayed match-to-place task for the water maze

The effect of the amino acid d-serine, a partial NMDA receptor agonist, on a delayed match-to-place task in the water maze was examined. Twenty-four male rats were first trained to attain baseline measurements, then administered d-serine or saline. Rats administered d-serine (100 mg/kg, i.p.) before...

Full description

Saved in:
Bibliographic Details
Published in:Behavioural brain research 2004-07, Vol.152 (2), p.447-452
Main Authors: Stouffer, Eric M, Petri, Herbert L, Devan, Bryan D
Format: Article
Language:English
Subjects:
Amino acid
Animal
Animals
Behavior, Animal
Behavioral psychophysiology
Biological and medical sciences
Escape Reaction - drug effects
Fundamental and applied biological sciences. Psychology
Hippocampus
Learning. Memory
Male
Maze Learning - drug effects
Memory
Multiple memory systems
Neurotransmission and behavior
NMDA receptor
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - agonists
Serine - pharmacology
Space Perception - drug effects
Spatial learning
Striatum
Task Performance and Analysis
Time Factors
Win-stay
Working memory
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of the amino acid d-serine, a partial NMDA receptor agonist, on a delayed match-to-place task in the water maze was examined. Twenty-four male rats were first trained to attain baseline measurements, then administered d-serine or saline. Rats administered d-serine (100 mg/kg, i.p.) before swim trials did not show a decrease in escape latencies, but did show an increase in swim time spent within the previous days’ escape platform location.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2003.10.008