Measurement of arterial wall thickness as a surrogate marker for atherosclerosis

Large observational studies and atherosclerosis regression trials of lipid-modifying pharmacotherapy have established that intima-media thickness of the carotid and femoral arteries, as measured noninvasively by B-mode ultrasound, is a valid surrogate marker for the progression of atherosclerotic di...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-06, Vol.109 (23 Suppl 1), p.III33-III38
Main Authors: de Groot, Eric, Hovingh, G Kees, Wiegman, Albert, Duriez, Patrick, Smit, Andries J, Fruchart, Jean-Charles, Kastelein, John J P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arteriosclerosis - diagnosis
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - epidemiology
Arteriosclerosis - etiology
Arteriosclerosis - pathology
Biomarkers
Cardiotonic Agents - therapeutic use
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Child
Child, Preschool
Clinical Trials as Topic
Computer Systems
Coronary Disease - drug therapy
Coronary Disease - epidemiology
Coronary Disease - prevention & control
Epidemiologic Research Design
Female
Femoral Artery - diagnostic imaging
Femoral Artery - pathology
Humans
Hyperlipoproteinemia Type II - complications
Hyperlipoproteinemia Type II - diagnostic imaging
Hyperlipoproteinemia Type II - drug therapy
Hyperlipoproteinemia Type II - epidemiology
Image Processing, Computer-Assisted
Male
Middle Aged
Netherlands - epidemiology
Risk
Tunica Intima - diagnostic imaging
Tunica Intima - pathology
Tunica Media - diagnostic imaging
Tunica Media - pathology
Ultrasonography
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Summary:Large observational studies and atherosclerosis regression trials of lipid-modifying pharmacotherapy have established that intima-media thickness of the carotid and femoral arteries, as measured noninvasively by B-mode ultrasound, is a valid surrogate marker for the progression of atherosclerotic disease. To exploit fully the potential of ultrasound imaging in atherosclerosis research, standardized and strictly implemented imaging protocols should be used in both observational studies and applied clinical research. This article describes such a protocol developed at the Academic Medical Center of the University of Amsterdam, the Netherlands. Results are presented from a study that estimated atherosclerosis progression from childhood into old age by measuring intima-media thickness in subjects with familial hypercholesterolemia compared with healthy controls.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000131516.65699.ba