Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease

• Published in: Atherosclerosis 2004-03, Vol.173 (1), p.109-114
• Main Authors: Szalai, Csaba, Keszei, Márton, Duba, Jenõ, Prohászka, Zoltán, Kozma, Gergely Tibor, Császár, Albert, Balogh, Sándor, Almássy, Zsuzsa, Fust, George, Czinner, Antal
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alleles; apoAV; Apolipoproteins A - genetics; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Base Sequence; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Case-Control Studies; Coronary Artery Bypass - methods; Coronary Artery Disease - diagnosis; Coronary Artery Disease - genetics; Coronary Artery Disease - surgery; Coronary bypass; Disease Susceptibility; Female; Genetic Predisposition to Disease; Humans; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Odds Ratio; Polymerase Chain Reaction; Polymorphism; Polymorphism, Genetic; Probability; Prognosis; Promoter Regions, Genetic; Reference Values; Risk Assessment; Severity of Illness Index; Triglyceride
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2003.12.003

Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of this polymorphism in 308 Hungarian patients with CAD referred to coronary bypass surgery, and in 310 controls recruited from the same area. The prevalence of the apoA5-1131C allele was significantly higher among CAD patients than among controls (10.9% versus 5.7%; P