Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity

Flow-mediated dilation (FMD) of the brachial artery, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) have been shown to be good surrogate markers of clinical atherosclerosis. We determined the interrelation between these measurements, and examined whether their combination would b...

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Bibliographic Details
Published in:Atherosclerosis 2004-03, Vol.173 (1), p.13-18
Main Authors: Kobayashi, Kumiko, Akishita, Masahiro, Yu, Wei, Hashimoto, Masayoshi, Ohni, Mitsuo, Toba, Kenji
Format: Article
Language:English
Subjects:
Aged
Arterial stiffness
Arteriosclerosis
Arteriosclerosis - diagnostic imaging
Arteriosclerosis - pathology
Arteriosclerosis - physiopathology
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity
Brachial Artery - diagnostic imaging
Cardiology. Vascular system
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Case-Control Studies
Diagnostic Techniques, Cardiovascular
Elasticity
Endothelium
Endothelium, Vascular - pathology
Female
Humans
Male
Medical sciences
Middle Aged
Probability
Reference Values
Regression Analysis
Sensitivity and Specificity
Severity of Illness Index
Tunica Intima - pathology
Ultrasonography, Doppler
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Summary:Flow-mediated dilation (FMD) of the brachial artery, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) have been shown to be good surrogate markers of clinical atherosclerosis. We determined the interrelation between these measurements, and examined whether their combination would be of clinical significance. One hundred and thirty-five consecutive subjects (79 women/56 men) were enrolled, including 110 patients with risk factors for atherosclerosis, and 33 patients with atherosclerotic disease such as coronary heart disease, stroke or arteriosclerosis obliterans. IMT and plaque formation of the carotid artery and FMD of the brachial artery were assessed using ultrasonography. Brachial-ankle PWV (baPWV) was measured using an automated device (form ABI/PWV, Colin). Age, FMD, IMT and PWV were significantly correlated with each other. Multivariate analysis revealed an independent correlation between the parameters except for FMD, and all four parameters were independently correlated with each other in subjects
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2003.10.013