Biophysical Analysis of Radiation Induced Initial DNA Fragmentation

Production of double strand breaks (DSBs) and double-stranded DNA fragments after irradiation with high energy nitrogen ions was simulated with stochastic track generation and a high-order chromatin structure (HOCS) model representing a segment of interphase chromosome. The non-random distribution o...

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Bibliographic Details
Published in:Radiation protection dosimetry 2002-01, Vol.99 (1-4), p.151-152
Main Authors: Khvostunov, I K, Andreev, S G, Eidelman, YuA
Format: Article
Language:English
Subjects:
Biophysics - methods
Chromatin - radiation effects
DNA - chemistry
DNA - radiation effects
DNA Fragmentation - radiation effects
Stochastic Processes
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Description
Summary:Production of double strand breaks (DSBs) and double-stranded DNA fragments after irradiation with high energy nitrogen ions was simulated with stochastic track generation and a high-order chromatin structure (HOCS) model representing a segment of interphase chromosome. The non-random distribution of DNA fragments is predicted for irradiation of HOCS. Agreement with the experimental data is obtained. The influence of HOCS and the role of the background component in DNA fragment distributions are discussed.
ISSN:0144-8420
1742-3406
DOI:10.1093/oxfordjournals.rpd.a006748