5-Hydroxytryptamine-Derived Alkaloids from Two Marine Sponges of the Genus Hyrtios

Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatus were found to contain 5-hydroxytryptamine-derived alkaloids. Their structures were determined on the basis of their spectral properties. H. erectus contained hyrtiosulawesine (4), a new β-carboline alkaloid, together with...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2002-08, Vol.65 (8), p.1173-1176
Main Authors: Salmoun, Mostafa, Devijver, Christine, Daloze, Désiré, Braekman, Jean-Claude, van Soest, Rob W. M
Format: Article
Language:English
Subjects:
5-hydroxytryptamine
Animals
Biological and medical sciences
Chromatography, Thin Layer
General pharmacology
Hyrtios erectus
Hyrtios reticulatus
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indonesia
Marine
Medical sciences
Molecular Structure
natural products
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Serotonin - analogs & derivatives
Serotonin - chemistry
Serotonin - isolation & purification
Spectrophotometry, Ultraviolet
Stereoisomerism
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Summary:Indonesian specimens of the marine sponges Hyrtios erectus and H. reticulatus were found to contain 5-hydroxytryptamine-derived alkaloids. Their structures were determined on the basis of their spectral properties. H. erectus contained hyrtiosulawesine (4), a new β-carboline alkaloid, together with the already known alkaloids 5-hydroxyindole-3-carbaldehyde (1), hyrtiosin B (2), and 5-hydroxy-3-(2-hydroxyethyl)indole (3). H. reticulatus contained the novel derivative 1,6-dihydroxy-1,2,3,4-tetrahydro-β-carboline (11) together with serotonin (5), 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline (7), and 6-hydroxy-3,4-dihydro-1-oxo-β-carboline (9).
ISSN:0163-3864
1520-6025
DOI:10.1021/np020009+