Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study

To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries. A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe...

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Bibliographic Details
Published in:Child's nervous system 2002-08, Vol.18 (8), p.368-374
Main Authors: TOLIAS, Christos M, RICHARDS, Douglas A, BOWERY, Norman G, SGOUROS, Spyros
Format: Article
Language:English
Subjects:
Adolescent
Analysis of Variance
Biological and medical sciences
Brain - metabolism
Child
Child, Preschool
Chromatography, High Pressure Liquid - methods
Craniocerebral Trauma - diagnosis
Craniocerebral Trauma - metabolism
Craniocerebral Trauma - physiopathology
Extracellular Space - metabolism
Female
Glasgow Coma Scale - standards
Glutamic Acid - metabolism
Glutamine - analysis
Glutamine - metabolism
Humans
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Microdialysis - methods
Monitoring, Physiologic - methods
Pilot Projects
Prognosis
Time Factors
Tomography, X-Ray Computed
Traumas. Diseases due to physical agents
Tyrosine - analysis
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Summary:To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries. A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe head injuries (Glasgow coma scale
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-002-0623-y