Loading…
Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study
To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries. A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe...
Saved in:
| Published in: | Child's nervous system 2002-08, Vol.18 (8), p.368-374 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c285t-4365340c29c13af80b1f84122ec307304b7c2214b47c0c66889d0e431dbe36b83 |
|---|---|
| cites | |
| container_end_page | 374 |
| container_issue | 8 |
| container_start_page | 368 |
| container_title | Child's nervous system |
| container_volume | 18 |
| creator | TOLIAS, Christos M RICHARDS, Douglas A BOWERY, Norman G SGOUROS, Spyros |
| description | To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries.
A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe head injuries (Glasgow coma scale |
| doi_str_mv | 10.1007/s00381-002-0623-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72027606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72027606</sourcerecordid><originalsourceid>FETCH-LOGICAL-c285t-4365340c29c13af80b1f84122ec307304b7c2214b47c0c66889d0e431dbe36b83</originalsourceid><addsrcrecordid>eNpF0LtOwzAYBWALgWgpPAAL8gKb4fcljsOGqnKRKrHAHDmOQ1w5SbEdIG9PEUVMZ_l0pHMQOqdwTQHymwjAFSUAjIBknEwHaE4F5wR4BodoDiyTJAcBM3QS4waAZooVx2hGGS2YKOQctauvFLSx3o9eB_zmx6Q7nSx2PU6txVXQro94aLBpna-D7fGnSy2O9sMGi1ur6x3djMHZeIs13jo_JNw5E4baaT9FF3FMYz2doqNG-2jP9rlAr_erl-UjWT8_PC3v1sQwlSUiuMy4AMMKQ7luFFS0UYIyZg2HnIOocsMYFZXIDRgplSpqsILTurJcVoov0NVv7zYM76ONqexc_NmnezuMscwZsFyC3MGLPRyrztblNrhOh6n8-2YHLvdAR6N9E3RvXPx3XGWKs5x_A49Nc8c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72027606</pqid></control><display><type>article</type><title>Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study</title><source>Springer Nature</source><creator>TOLIAS, Christos M ; RICHARDS, Douglas A ; BOWERY, Norman G ; SGOUROS, Spyros</creator><creatorcontrib>TOLIAS, Christos M ; RICHARDS, Douglas A ; BOWERY, Norman G ; SGOUROS, Spyros</creatorcontrib><description>To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries.
A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe head injuries (Glasgow coma scale<8). Dialysate samples were collected hourly and analysed, using High Performance Liquid Chromatography (HPLC), for glutamate, glutamine and various structural amino acids. Clinical monitoring parameters were also correlated with amino acid concentrations.
Mean glutamate concentrations in the dialysate varied from very low (<5 micro M) to very high (>30 micro M). No correlation with outcome at discharge was demonstrated. Structural amino acid levels did not follow the glutamate fluctuations. Low glutamine/glutamate ratio was associated with increased morbidity, while a high ratio was associated with clinical improvement. Glutamate metabolism may have a more significant role in the pathophysiology of paediatric head injury than has already been recognised.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-002-0623-y</identifier><identifier>PMID: 12192496</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Analysis of Variance ; Biological and medical sciences ; Brain - metabolism ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid - methods ; Craniocerebral Trauma - diagnosis ; Craniocerebral Trauma - metabolism ; Craniocerebral Trauma - physiopathology ; Extracellular Space - metabolism ; Female ; Glasgow Coma Scale - standards ; Glutamic Acid - metabolism ; Glutamine - analysis ; Glutamine - metabolism ; Humans ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Male ; Medical sciences ; Microdialysis - methods ; Monitoring, Physiologic - methods ; Pilot Projects ; Prognosis ; Time Factors ; Tomography, X-Ray Computed ; Traumas. Diseases due to physical agents ; Tyrosine - analysis</subject><ispartof>Child's nervous system, 2002-08, Vol.18 (8), p.368-374</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-4365340c29c13af80b1f84122ec307304b7c2214b47c0c66889d0e431dbe36b83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13858327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12192496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOLIAS, Christos M</creatorcontrib><creatorcontrib>RICHARDS, Douglas A</creatorcontrib><creatorcontrib>BOWERY, Norman G</creatorcontrib><creatorcontrib>SGOUROS, Spyros</creatorcontrib><title>Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries.
A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe head injuries (Glasgow coma scale<8). Dialysate samples were collected hourly and analysed, using High Performance Liquid Chromatography (HPLC), for glutamate, glutamine and various structural amino acids. Clinical monitoring parameters were also correlated with amino acid concentrations.
Mean glutamate concentrations in the dialysate varied from very low (<5 micro M) to very high (>30 micro M). No correlation with outcome at discharge was demonstrated. Structural amino acid levels did not follow the glutamate fluctuations. Low glutamine/glutamate ratio was associated with increased morbidity, while a high ratio was associated with clinical improvement. Glutamate metabolism may have a more significant role in the pathophysiology of paediatric head injury than has already been recognised.</description><subject>Adolescent</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Craniocerebral Trauma - diagnosis</subject><subject>Craniocerebral Trauma - metabolism</subject><subject>Craniocerebral Trauma - physiopathology</subject><subject>Extracellular Space - metabolism</subject><subject>Female</subject><subject>Glasgow Coma Scale - standards</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamine - analysis</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdialysis - methods</subject><subject>Monitoring, Physiologic - methods</subject><subject>Pilot Projects</subject><subject>Prognosis</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Tyrosine - analysis</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpF0LtOwzAYBWALgWgpPAAL8gKb4fcljsOGqnKRKrHAHDmOQ1w5SbEdIG9PEUVMZ_l0pHMQOqdwTQHymwjAFSUAjIBknEwHaE4F5wR4BodoDiyTJAcBM3QS4waAZooVx2hGGS2YKOQctauvFLSx3o9eB_zmx6Q7nSx2PU6txVXQro94aLBpna-D7fGnSy2O9sMGi1ur6x3djMHZeIs13jo_JNw5E4baaT9FF3FMYz2doqNG-2jP9rlAr_erl-UjWT8_PC3v1sQwlSUiuMy4AMMKQ7luFFS0UYIyZg2HnIOocsMYFZXIDRgplSpqsILTurJcVoov0NVv7zYM76ONqexc_NmnezuMscwZsFyC3MGLPRyrztblNrhOh6n8-2YHLvdAR6N9E3RvXPx3XGWKs5x_A49Nc8c</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>TOLIAS, Christos M</creator><creator>RICHARDS, Douglas A</creator><creator>BOWERY, Norman G</creator><creator>SGOUROS, Spyros</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020801</creationdate><title>Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study</title><author>TOLIAS, Christos M ; RICHARDS, Douglas A ; BOWERY, Norman G ; SGOUROS, Spyros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-4365340c29c13af80b1f84122ec307304b7c2214b47c0c66889d0e431dbe36b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Craniocerebral Trauma - diagnosis</topic><topic>Craniocerebral Trauma - metabolism</topic><topic>Craniocerebral Trauma - physiopathology</topic><topic>Extracellular Space - metabolism</topic><topic>Female</topic><topic>Glasgow Coma Scale - standards</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamine - analysis</topic><topic>Glutamine - metabolism</topic><topic>Humans</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdialysis - methods</topic><topic>Monitoring, Physiologic - methods</topic><topic>Pilot Projects</topic><topic>Prognosis</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Tyrosine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOLIAS, Christos M</creatorcontrib><creatorcontrib>RICHARDS, Douglas A</creatorcontrib><creatorcontrib>BOWERY, Norman G</creatorcontrib><creatorcontrib>SGOUROS, Spyros</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOLIAS, Christos M</au><au>RICHARDS, Douglas A</au><au>BOWERY, Norman G</au><au>SGOUROS, Spyros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>18</volume><issue>8</issue><spage>368</spage><epage>374</epage><pages>368-374</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>To determine, using a microdialysis technique, the extracellular levels of glutamate and non-transmitter amino acids in the brain of children with severe head injuries.
A microdialysis probe was inserted along side the intracranial pressure (ICP) bolt in 9 children (age range 2-14 years) with severe head injuries (Glasgow coma scale<8). Dialysate samples were collected hourly and analysed, using High Performance Liquid Chromatography (HPLC), for glutamate, glutamine and various structural amino acids. Clinical monitoring parameters were also correlated with amino acid concentrations.
Mean glutamate concentrations in the dialysate varied from very low (<5 micro M) to very high (>30 micro M). No correlation with outcome at discharge was demonstrated. Structural amino acid levels did not follow the glutamate fluctuations. Low glutamine/glutamate ratio was associated with increased morbidity, while a high ratio was associated with clinical improvement. Glutamate metabolism may have a more significant role in the pathophysiology of paediatric head injury than has already been recognised.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12192496</pmid><doi>10.1007/s00381-002-0623-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 2002-08, Vol.18 (8), p.368-374 |
| issn | 0256-7040 1433-0350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72027606 |
| source | Springer Nature |
| subjects | Adolescent Analysis of Variance Biological and medical sciences Brain - metabolism Child Child, Preschool Chromatography, High Pressure Liquid - methods Craniocerebral Trauma - diagnosis Craniocerebral Trauma - metabolism Craniocerebral Trauma - physiopathology Extracellular Space - metabolism Female Glasgow Coma Scale - standards Glutamic Acid - metabolism Glutamine - analysis Glutamine - metabolism Humans Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Microdialysis - methods Monitoring, Physiologic - methods Pilot Projects Prognosis Time Factors Tomography, X-Ray Computed Traumas. Diseases due to physical agents Tyrosine - analysis |
| title | Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A28%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extracellular%20glutamate%20in%20the%20brains%20of%20children%20with%20severe%20head%20injuries:%20a%20pilot%20microdialysis%20study&rft.jtitle=Child's%20nervous%20system&rft.au=TOLIAS,%20Christos%20M&rft.date=2002-08-01&rft.volume=18&rft.issue=8&rft.spage=368&rft.epage=374&rft.pages=368-374&rft.issn=0256-7040&rft.eissn=1433-0350&rft_id=info:doi/10.1007/s00381-002-0623-y&rft_dat=%3Cproquest_pubme%3E72027606%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c285t-4365340c29c13af80b1f84122ec307304b7c2214b47c0c66889d0e431dbe36b83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=72027606&rft_id=info:pmid/12192496&rfr_iscdi=true |