Actinic prurigo cheilitis: Clinicopathologic analysis and therapeutic results in 116 cases

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2002-07, Vol.94 (1), p.83-91
• Main Authors: Vega-Memije, María Elisa, Mosqueda-Taylor, Adalberto, Irigoyen-Camacho, María Esther, Hojyo-Tomoka, María Teresa, Domínguez-Soto, Luciano
• Format: Article
• Language: English
• Subjects: Administration, Topical; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Cheilitis - complications; Cheilitis - drug therapy; Cheilitis - etiology; Cheilitis - pathology; Chi-Square Distribution; Child; Dentistry; Dermatologic Agents - therapeutic use; Dermatology; Drug Combinations; Female; Glucocorticoids; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases; Otorhinolaryngology. Stomatology; Photosensitivity Disorders - drug therapy; Photosensitivity Disorders - pathology; Prurigo - complications; Prurigo - drug therapy; Prurigo - etiology; Prurigo - pathology; Regression Analysis; Retrospective Studies; Skin involvement in other diseases. Miscellaneous. General aspects; Sunlight - adverse effects; Sunscreening Agents - therapeutic use; Thalidomide - therapeutic use; Tropical medicine; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1067/moe.2002.123539

Objective. This study describes the clinicopathologic features and therapeutic results of 116 patients with actinic prurigo cheilitis seen over an 11-year period. Study Design. A retrospective study was carried out with hospital records and a microscopic slide review from a large dermatology department in Mexico City, Mexico. Results. The study consisted of 42 male (36.2%) and 74 female (63.8%) patients, with a male to female ratio of 1:1.7. Age ranged from 9 to 82 years (mean, 27.9 years; standard deviation, 14.2). Thirty-two cases (27.6%) were found in which cheilitis was the only manifestation of this condition. Pruritus, tingling, and pain of the vermilion were recorded in 96 cases (82.7%). Typical histopathologic findings included in most cases the presence of acanthosis, spongiosis, basal cell vacuolation, ulceration with serohematic crust formation, edema of the lamina propria, lymphocytic inflammatory infiltrate with well-defined lymphoid follicles, and variable numbers of eosinophils and melanophages. Improvement of the symptoms was obtained in 112 cases (96.5%) with sun-protective measures and diverse antiinflammatory agents. However, complete resolution of the labial lesions were more frequently achieved with the combination of topical steroids, thalidomide, and sun-protective measures (42.2%) as compared with topical steroid therapy plus sun-protection measures (16.3%; P