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SAR by MS: A Ligand Based Technique for Drug Lead Discovery Against Structured RNA Targets
A technique for lead discovery vs RNA targets utilizing mass spectrometry (MS) screening methods is described. The structure−activity relationships (SAR) derived from assaying weak binding motifs allows the pharmacophores discovered to be elaborated via “SAR by MS” to higher affinity ligands. Applic...
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Published in: | Journal of medicinal chemistry 2002-08, Vol.45 (18), p.3816-3819 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A technique for lead discovery vs RNA targets utilizing mass spectrometry (MS) screening methods is described. The structure−activity relationships (SAR) derived from assaying weak binding motifs allows the pharmacophores discovered to be elaborated via “SAR by MS” to higher affinity ligands. Application of this strategy to a subdomain of the 23S rRNA afforded a new class of compounds with functional activity. |
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ISSN: | 0022-2623 1520-4804 |
DOI: | 10.1021/jm0255466 |