A novel regiospecific N to O-methyl transferase activity in the biotransformation of a thebaine derivative with Cunninghamella echinulata NRRL 1384

A novel regiospecific N- to O-methyl transfer reaction has been characterised in the biotransformation of an N-CD3-thebaine derivative with the fungus Cunninghamella echinulata NRRL 1384.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2002-08 (16), p.1762-1763
Main Authors: Abel, Anthony M, Allan, Graham R, Carnell, Andrew J, Davis, J Alf
Format: Article
Language:English
Subjects:
Biotransformation
Cunninghamella - enzymology
Cunninghamella - metabolism
Deuterium
Fermentation
Methylation
Substrate Specificity
Thebaine - metabolism
Transferases - metabolism
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Description
Summary:A novel regiospecific N- to O-methyl transfer reaction has been characterised in the biotransformation of an N-CD3-thebaine derivative with the fungus Cunninghamella echinulata NRRL 1384.
ISSN:1359-7345
1364-548X
DOI:10.1039/b204697k