Age-related differences in the effect of running training on cardiac Myosin isozyme composition in rats

We examined the effect of running training on age-related changes in cardiac myosin isozyme composition in rats. Female Fischer 344 rats (6, 12, 20, and 27 months old) were divided into two groups: sedentary control and trained. The trained group rats were trained by treadmill running for up to 60 m...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2002-09, Vol.57 (9), p.B339-B343
Main Authors: Machida, Shuichi, Tsujimoto, Hisaya, Suzuki, Hideki, Kasuga, Norikatsu, Kobayashi, Keizo, Narusawa, Mitsuo
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Female
Heart
Myocardium - enzymology
Physical Conditioning, Animal - physiology
Rats
Rats, Inbred F344
Rodents
Running
Running - physiology
Ventricular Myosins - analysis
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Summary:We examined the effect of running training on age-related changes in cardiac myosin isozyme composition in rats. Female Fischer 344 rats (6, 12, 20, and 27 months old) were divided into two groups: sedentary control and trained. The trained group rats were trained by treadmill running for up to 60 minutes per day, 5 days per week for 8 weeks at up to 30 m per minute. In sedentary control rats, the proportion of V1 myosin, that is, alpha-myosin heavy chain (MyHC) isoform, decreased progressively from 6 to 27 months of age. In the younger age groups (6 or 12 months old), there was a shift from V1 myosin to V3 myosin (beta-MyHC isoform) in trained hearts. However, the training program did not induce a cardiac myosin isozyme transition in older rats (20 or 27 months old). These results suggest that the mechanisms mediating the responses of cardiac muscle to running training alter during aging.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/57.9.B339