t(8;21)(q22;q22) in blast phase of chronic myelogenous leukemia

The blast phase of chronic myelogenous leukemia (CML) frequently is associated with cytogenetic evidence of clonal evolution, defined as chromosomal aberrations in addition to the t(9;22)(q34;q11.2). We identified the t(8;21)(q22;q22) and other cytogenetic abnormalities by conventional cytogenetics...

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Bibliographic Details
Published in:American journal of clinical pathology 2004-06, Vol.121 (6), p.836-842
Main Authors: YIN, C. Cameron, MEDEIROS, L. Jeffrey, GLASSMAN, Armand B, PEI LIN
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blast Crisis - genetics
Bone Marrow - metabolism
Bone Marrow - pathology
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Female
Flow Cytometry
General aspects
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Salmonidae
Translocation, Genetic
Tumors
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Summary:The blast phase of chronic myelogenous leukemia (CML) frequently is associated with cytogenetic evidence of clonal evolution, defined as chromosomal aberrations in addition to the t(9;22)(q34;q11.2). We identified the t(8;21)(q22;q22) and other cytogenetic abnormalities by conventional cytogenetics and fluorescence in situ hybridization in 2 patients with t(9;22)-positive CML at the time of blast phase. The t(8;21), which typically is associated with a distinct subtype of de novo acute myeloid leukemia (AML) carrying the aml1/eto fusion gene, was accompanied by increased bone marrow myeloblasts (33%) in case 1 and extramedullary myeloid sarcoma in case 2, suggesting its possible role in disease progression. In case 1, the leukemic cells in aspirate smears had salmon-colored cytoplasmic granules, and immunophenotypic studies showed that the blasts expressed CD19. These findings suggest that the pathologic features of blast phase CML with the t(8;21) resemble those of de novo AML with the t(8;21).
ISSN:0002-9173
1943-7722
DOI:10.1309/H8JH6L094B9U3HGT