A 3-month comparison of 1% and 2% carteolol and 0.5% timolol in open-angle glaucoma

Carteolol, a nonselective beta-adrenergic antagonist with intrinsic sympathomimetic activity, was compared in 1% and 2% topical solutions with 0.5% timolol in 105 patients with primary open-angle glaucoma. In this double-masked, randomized 3-month trial, all three preparations significantly lowered...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 1991, Vol.229 (3), p.258-261
Main Authors: STEWART, W. C, SHIELDS, M. B, ALLEN, R. C, LEWIS, R. A, COHEN, J. S, HOSKINS, H. D, HETHERINGTON, J. N, BAHR, R. L, NOBLIN, J. E, DELEHANTY, J. T
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Pressure - drug effects
Carteolol - therapeutic use
Dosage Forms
Double-Blind Method
Eye
Female
Glaucoma, Open-Angle - drug therapy
Heart Rate - drug effects
Humans
Intraocular Pressure - drug effects
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Timolol - therapeutic use
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Summary:Carteolol, a nonselective beta-adrenergic antagonist with intrinsic sympathomimetic activity, was compared in 1% and 2% topical solutions with 0.5% timolol in 105 patients with primary open-angle glaucoma. In this double-masked, randomized 3-month trial, all three preparations significantly lowered intraocular pressure throughout the study, with no significant differences being observed. There were also no significant differences among the three preparations with regard to ocular or systemic adverse reactions, including heart rate and blood pressure.
ISSN:0721-832X
1435-702X
DOI:10.1007/bf00167880