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Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance
Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accura...
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| Published in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2004-07, Vol.19 (7), p.1835-1841 |
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| creator | Magnasco, Alberto Bacchini, Giuseppe Cappello, Antonio La Milia, Vincenzo Brezzi, Brigida Messa, PierGiorgio Locatelli, Francesco |
| description | Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accuracy of GPT in a graft surveillance protocol with sequential Qa measurements. Methods. In 30 chronic haemodialysis patients with graft, we compared monthly sequential Qa measurements performed with GPT in pre-dialysis and the ultrasound dilution technique (HD01 device Transonic Systems Inc., USA) during dialysis. The colour Doppler ultrasonography study (CDU) was our reference standard for the diagnosis of stenosis. The endpoints were the graft thrombosis or PTA treatment. Results. According to the K/DOQI guidelines we could identify the thrombosis high-risk grafts when Qa was 600 ml/min and ΔQa |
| doi_str_mv | 10.1093/ndt/gfh292 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72032263</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72032263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-91fdf7ef01785323e9568a6910fbd7d784937a81c3f19598c75973fb0f4609193</originalsourceid><addsrcrecordid>eNpNkMuOEzEQRS0EYsLAhg9A3oAAqRm7HbftJYqYGWAkWAQJsbEcPxKDu934EZgVv45DImBVizp1VfcA8BijVxgJcjGZcrF1u170d8ACLwfU9YTTu2DRlrhDFIkz8CDnrwgh0TN2H5xhigcsKFqAX6vgJ69VgHsVvFHFxwlGB7eh6pgtnOs4w2Jzgc-vPq5fQB3HWSVr4A9fdrCGklSOdTLQ-FD_HBerd1MMcXsL_QRVKjb5uLdTrBluk3IF5pr21oegJm0fgntOhWwfneY5-HT5Zr267m4-XL1dvb7pNOGsdAI745h1CDNOSU-soANXg8DIbQwzjC8FYYpjTVzrJbhmVDDiNsg1HQILcg6eHXPnFL_X1keOPmt7eMK2zyTrEen7gTTw5RHUKeacrJNz8qNKtxIjedAtm2551N3gJ6fUuhmt-Yee_Dbg6QlQuUl2qXX2-T9O0CXnh6DuyPlc7M-_e5W-yYERRuX15y8SD-v1O3r5XgryG3yEmf0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72032263</pqid></control><display><type>article</type><title>Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance</title><source>Oxford Journals Online</source><creator>Magnasco, Alberto ; Bacchini, Giuseppe ; Cappello, Antonio ; La Milia, Vincenzo ; Brezzi, Brigida ; Messa, PierGiorgio ; Locatelli, Francesco</creator><creatorcontrib>Magnasco, Alberto ; Bacchini, Giuseppe ; Cappello, Antonio ; La Milia, Vincenzo ; Brezzi, Brigida ; Messa, PierGiorgio ; Locatelli, Francesco</creatorcontrib><description>Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accuracy of GPT in a graft surveillance protocol with sequential Qa measurements. Methods. In 30 chronic haemodialysis patients with graft, we compared monthly sequential Qa measurements performed with GPT in pre-dialysis and the ultrasound dilution technique (HD01 device Transonic Systems Inc., USA) during dialysis. The colour Doppler ultrasonography study (CDU) was our reference standard for the diagnosis of stenosis. The endpoints were the graft thrombosis or PTA treatment. Results. According to the K/DOQI guidelines we could identify the thrombosis high-risk grafts when Qa was <600 ml/min or <1000 ml/min with a decrease >25% in serial Qa measurements. HD01 yielded 27 of 112 high-risk Qa measurements (21 Qa <600 ml/min; mean 406±145 ml/min; 6 ΔQa >25%; mean 43±7%). In 12 of 27 cases the CDU control did not show haemodynamically significant stenoses (false positive); 15 of 27 cases were confirmed high-risk accesses by CDU and did PTAs (HD01 specificity 86%). GPT yielded 14 of 112 high-risk Qa measurements (8 Qa <600 ml/min; mean 404±135 ml/min; 6 ΔQa >25%; mean 38±8%) and all had severe stenoses and underwent PTA treatments showing a GPT specificity of 100%. The CDU study allowed us to correctly assess the Qa negative cases. HD01 method had 10 false negative cases (treated or clotted grafts with a Qa >600 ml/min and ΔQa <25%) with a sensitivity of 60%, while GPT had 11 false negative cases with a sensitivity of 56%. The diagnostic accuracy tested with the ROC curves was similar with both tests (area under the curve was 0.762 and 0.752 with GPT and ultrasound dilution, respectively; P = 0.985). The diagnostic efficiency (percentage of grafts with agreement between test result and factual situation) was 90 and 80% (P = 0.056) for GPT and HD01, respectively. Conclusion. Compared with HD01, the GPT had a lower false positive rate and similar diagnostic accuracy and efficiency. The clinical implication is a smaller number of unnecessary, invasive procedures (angiographies or PTAs), without increasing the thrombosis risk. This study has shown that GPT is an accurate, quick and economic test for Qa monitoring.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfh292</identifier><identifier>PMID: 15161950</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arteriovenous Shunt, Surgical ; Biological and medical sciences ; Blood Glucose - analysis ; Catheters, Indwelling ; colour Doppler ultrasound ; Diseases of the cardiovascular system ; Emergency and intensive care: renal failure. Dialysis management ; Female ; haemodialysis ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regional Blood Flow ; Renal Dialysis ; Reproducibility of Results ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Ultrasonography, Doppler, Color ; ultrasound dilution technology ; vascular access</subject><ispartof>Nephrology, dialysis, transplantation, 2004-07, Vol.19 (7), p.1835-1841</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-91fdf7ef01785323e9568a6910fbd7d784937a81c3f19598c75973fb0f4609193</citedby><cites>FETCH-LOGICAL-c387t-91fdf7ef01785323e9568a6910fbd7d784937a81c3f19598c75973fb0f4609193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15954882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15161950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magnasco, Alberto</creatorcontrib><creatorcontrib>Bacchini, Giuseppe</creatorcontrib><creatorcontrib>Cappello, Antonio</creatorcontrib><creatorcontrib>La Milia, Vincenzo</creatorcontrib><creatorcontrib>Brezzi, Brigida</creatorcontrib><creatorcontrib>Messa, PierGiorgio</creatorcontrib><creatorcontrib>Locatelli, Francesco</creatorcontrib><title>Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accuracy of GPT in a graft surveillance protocol with sequential Qa measurements. Methods. In 30 chronic haemodialysis patients with graft, we compared monthly sequential Qa measurements performed with GPT in pre-dialysis and the ultrasound dilution technique (HD01 device Transonic Systems Inc., USA) during dialysis. The colour Doppler ultrasonography study (CDU) was our reference standard for the diagnosis of stenosis. The endpoints were the graft thrombosis or PTA treatment. Results. According to the K/DOQI guidelines we could identify the thrombosis high-risk grafts when Qa was <600 ml/min or <1000 ml/min with a decrease >25% in serial Qa measurements. HD01 yielded 27 of 112 high-risk Qa measurements (21 Qa <600 ml/min; mean 406±145 ml/min; 6 ΔQa >25%; mean 43±7%). In 12 of 27 cases the CDU control did not show haemodynamically significant stenoses (false positive); 15 of 27 cases were confirmed high-risk accesses by CDU and did PTAs (HD01 specificity 86%). GPT yielded 14 of 112 high-risk Qa measurements (8 Qa <600 ml/min; mean 404±135 ml/min; 6 ΔQa >25%; mean 38±8%) and all had severe stenoses and underwent PTA treatments showing a GPT specificity of 100%. The CDU study allowed us to correctly assess the Qa negative cases. HD01 method had 10 false negative cases (treated or clotted grafts with a Qa >600 ml/min and ΔQa <25%) with a sensitivity of 60%, while GPT had 11 false negative cases with a sensitivity of 56%. The diagnostic accuracy tested with the ROC curves was similar with both tests (area under the curve was 0.762 and 0.752 with GPT and ultrasound dilution, respectively; P = 0.985). The diagnostic efficiency (percentage of grafts with agreement between test result and factual situation) was 90 and 80% (P = 0.056) for GPT and HD01, respectively. Conclusion. Compared with HD01, the GPT had a lower false positive rate and similar diagnostic accuracy and efficiency. The clinical implication is a smaller number of unnecessary, invasive procedures (angiographies or PTAs), without increasing the thrombosis risk. This study has shown that GPT is an accurate, quick and economic test for Qa monitoring.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arteriovenous Shunt, Surgical</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Catheters, Indwelling</subject><subject>colour Doppler ultrasound</subject><subject>Diseases of the cardiovascular system</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Regional Blood Flow</subject><subject>Renal Dialysis</subject><subject>Reproducibility of Results</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Ultrasonography, Doppler, Color</subject><subject>ultrasound dilution technology</subject><subject>vascular access</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpNkMuOEzEQRS0EYsLAhg9A3oAAqRm7HbftJYqYGWAkWAQJsbEcPxKDu934EZgVv45DImBVizp1VfcA8BijVxgJcjGZcrF1u170d8ACLwfU9YTTu2DRlrhDFIkz8CDnrwgh0TN2H5xhigcsKFqAX6vgJ69VgHsVvFHFxwlGB7eh6pgtnOs4w2Jzgc-vPq5fQB3HWSVr4A9fdrCGklSOdTLQ-FD_HBerd1MMcXsL_QRVKjb5uLdTrBluk3IF5pr21oegJm0fgntOhWwfneY5-HT5Zr267m4-XL1dvb7pNOGsdAI745h1CDNOSU-soANXg8DIbQwzjC8FYYpjTVzrJbhmVDDiNsg1HQILcg6eHXPnFL_X1keOPmt7eMK2zyTrEen7gTTw5RHUKeacrJNz8qNKtxIjedAtm2551N3gJ6fUuhmt-Yee_Dbg6QlQuUl2qXX2-T9O0CXnh6DuyPlc7M-_e5W-yYERRuX15y8SD-v1O3r5XgryG3yEmf0</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Magnasco, Alberto</creator><creator>Bacchini, Giuseppe</creator><creator>Cappello, Antonio</creator><creator>La Milia, Vincenzo</creator><creator>Brezzi, Brigida</creator><creator>Messa, PierGiorgio</creator><creator>Locatelli, Francesco</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance</title><author>Magnasco, Alberto ; Bacchini, Giuseppe ; Cappello, Antonio ; La Milia, Vincenzo ; Brezzi, Brigida ; Messa, PierGiorgio ; Locatelli, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-91fdf7ef01785323e9568a6910fbd7d784937a81c3f19598c75973fb0f4609193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arteriovenous Shunt, Surgical</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Catheters, Indwelling</topic><topic>colour Doppler ultrasound</topic><topic>Diseases of the cardiovascular system</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Regional Blood Flow</topic><topic>Renal Dialysis</topic><topic>Reproducibility of Results</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Ultrasonography, Doppler, Color</topic><topic>ultrasound dilution technology</topic><topic>vascular access</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magnasco, Alberto</creatorcontrib><creatorcontrib>Bacchini, Giuseppe</creatorcontrib><creatorcontrib>Cappello, Antonio</creatorcontrib><creatorcontrib>La Milia, Vincenzo</creatorcontrib><creatorcontrib>Brezzi, Brigida</creatorcontrib><creatorcontrib>Messa, PierGiorgio</creatorcontrib><creatorcontrib>Locatelli, Francesco</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magnasco, Alberto</au><au>Bacchini, Giuseppe</au><au>Cappello, Antonio</au><au>La Milia, Vincenzo</au><au>Brezzi, Brigida</au><au>Messa, PierGiorgio</au><au>Locatelli, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>19</volume><issue>7</issue><spage>1835</spage><epage>1841</epage><pages>1835-1841</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Blood flow (Qa) measurements are an important step in the surveillance protocol of haemodialysis vascular access (VA). The glucose pump test (GPT) is a new test for Qa measurement based on the dilution of a constant glucose infusion. The aim of this study is to verify the clinical accuracy of GPT in a graft surveillance protocol with sequential Qa measurements. Methods. In 30 chronic haemodialysis patients with graft, we compared monthly sequential Qa measurements performed with GPT in pre-dialysis and the ultrasound dilution technique (HD01 device Transonic Systems Inc., USA) during dialysis. The colour Doppler ultrasonography study (CDU) was our reference standard for the diagnosis of stenosis. The endpoints were the graft thrombosis or PTA treatment. Results. According to the K/DOQI guidelines we could identify the thrombosis high-risk grafts when Qa was <600 ml/min or <1000 ml/min with a decrease >25% in serial Qa measurements. HD01 yielded 27 of 112 high-risk Qa measurements (21 Qa <600 ml/min; mean 406±145 ml/min; 6 ΔQa >25%; mean 43±7%). In 12 of 27 cases the CDU control did not show haemodynamically significant stenoses (false positive); 15 of 27 cases were confirmed high-risk accesses by CDU and did PTAs (HD01 specificity 86%). GPT yielded 14 of 112 high-risk Qa measurements (8 Qa <600 ml/min; mean 404±135 ml/min; 6 ΔQa >25%; mean 38±8%) and all had severe stenoses and underwent PTA treatments showing a GPT specificity of 100%. The CDU study allowed us to correctly assess the Qa negative cases. HD01 method had 10 false negative cases (treated or clotted grafts with a Qa >600 ml/min and ΔQa <25%) with a sensitivity of 60%, while GPT had 11 false negative cases with a sensitivity of 56%. The diagnostic accuracy tested with the ROC curves was similar with both tests (area under the curve was 0.762 and 0.752 with GPT and ultrasound dilution, respectively; P = 0.985). The diagnostic efficiency (percentage of grafts with agreement between test result and factual situation) was 90 and 80% (P = 0.056) for GPT and HD01, respectively. Conclusion. Compared with HD01, the GPT had a lower false positive rate and similar diagnostic accuracy and efficiency. The clinical implication is a smaller number of unnecessary, invasive procedures (angiographies or PTAs), without increasing the thrombosis risk. This study has shown that GPT is an accurate, quick and economic test for Qa monitoring.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15161950</pmid><doi>10.1093/ndt/gfh292</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arteriovenous Shunt, Surgical Biological and medical sciences Blood Glucose - analysis Catheters, Indwelling colour Doppler ultrasound Diseases of the cardiovascular system Emergency and intensive care: renal failure. Dialysis management Female haemodialysis Humans Intensive care medicine Male Medical sciences Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Regional Blood Flow Renal Dialysis Reproducibility of Results Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Ultrasonography, Doppler, Color ultrasound dilution technology vascular access |
| title | Clinical validation of glucose pump test (GPT) compared with ultrasound dilution technology in arteriovenous graft surveillance |
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